13165-15-6

Basic information

• Product Name: 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE
• Synonyms: 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE;7-Chloro-3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one;7-Chloro-2,3-dihydro-3-phenyl-2-thioxo-1H-quinazolin-4-one
• CAS NO: 13165-15-6
• Molecular Formula: C₁₄H₉ClN₂OS
• Molecular Weight: 288.75206
• Mol File: 13165-15-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 323-324
• Boiling Point: 438.3 °C at 760 mmHg
• Flash Point: 218.9 °C
• Appearance: /
• Density: 1.5 g/cm³
• Vapor Pressure: 7.01E-08mmHg at 25°C
• Refractive Index: 1.753
• PKA: 10.35±0.20(Predicted)
• CAS DataBase Reference: 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE(13165-15-6)
• EPA Substance Registry System: 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE(13165-15-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 13165-15-6(Hazardous Substances Data)

Usage

General Description

7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE, also known as CI-1011, is a chemical compound with a quinazolinone backbone. It contains a chloro group at the 7th position, a phenyl group at the 3rd position, and a thioxo group at the 2nd position. 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE has potential pharmacological significance due to its reported biological activities, including anticonvulsant, antimicrobial, and anticancer properties. It has also been studied for its potential use as an anxiolytic and sedative agent. Further research and testing are needed to fully understand and utilize the properties and potential applications of 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE.

InChI:InChI=1/C14H9ClN2OS/c15-9-6-7-11-12(8-9)16-14(19)17(13(11)18)10-4-2-1-3-5-10/h1-8H,(H,16,19)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 40928-13-0 4-chloroisatoic anhydride 
• 108-88-3 toluene 
• 1156892-37-3 C₉H₈ClNO₄ 

Downstream Products

• 80806-82-2 7-Chloro-3-phenyl-24(3H)-quinazolinone 
• 1221129-68-5 2-mercapto-7-morpholino-3-phenylquinazolin-4(3H)-one 
• 80806-81-1 7-Chloro-3-phenyl-2-carboxymethylthio-4(3H)-quinazolinone 
• 15641-57-3 7-chloro-2-(2-dimethylamino-ethylsulfanyl)-3-phenyl-3H-quinazolin-4-one 
• 80806-80-0 7-Chloro-3-phenyl-2-carbethoxymethylthio-4(3H)-quinazolinone 

Relevant articles and documents

KF/Al2O3 catalyzed one-pot three-component process for the synthesis of some 2-thioxoquinazolin-4(1h)-one derivatives

Three component one-pot reaction for synthesis of 2-thioxoquinazolin-4(1H)- ones are given by the condensation of isatoic anhydride, primary amine and phenyl isothiocyanate by using KF/Al2O3 as a environmentally friendly catalyst.

One-pot synthesis of quinazoline-2,4(1H,3H)-diones and 2- thioxoquinazolinones with the aid of low-valent titanium reagent

(Chemical Equation Presented) An efficient, convenient, one-pot synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolinones was accomplished in good yields via the novel reductive cyclization of ethyl 2-nitrobenzoates with isocyanates or isothioc

2-thio-organotin-4(3H)-quinazolinone

Compounds of the formula: STR1 wherein X is independently halogen, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, nitro, lower alkylsulfinyl of 1 to 6 carbon atoms, lower alkylthio of 1 to 6 carbon atoms, amino or trifluoromethyl; n is 0, 1, 2 or 3; R is hydrogen, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, or lower alkynyl of 2 to 6 carbon atoms, all optionally substituted with 1 to 3 of the same or different halogen atoms; or aryl of 6 to 12 carbon atoms; or substituted aryl substituted with 1 to 3 substituents independently selected from lower alkyl of 1 to 4 carbon atoms, lower alkoxy of 1 to 4 carbon atoms, and the group --S(O)k R2 where k is 0, 1 or 2 and R2 is lower alkyl of 1 to 4 carbon atoms, nitro, cyano or halogen; and R1 is lower alkyl of 1 to 6 carbon atoms, lower cycloalkyl of 3 to 8 carbon atoms or aryl of 6 to 12 carbon atoms, provided that R and R1 are not both cyclohexyl, are fungicidal and in some cases insecticidal.