13165-77-0

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 7732-18-5 water 
• 64116-38-7 toluene-2-sulfonic acid-(N'-o-tolyl-hydrazide) 
• 63369-67-5 2-methylbenzenesulfinyl chloride 
• 96097-69-7 S-phenyl 2-methylbenzenesulfonothioate 

Downstream Products

• 876658-04-7 (E)-1-chloro-1,2-bis-(toluene-2-sulfonyl)-ethene 
• 88-19-7 methyl 2-(aminosulfonyl)benzoate 
• 88-20-0 o-toluenesulfonic acid 
• 38045-42-0 S-(2-methylphenyl) 2-methylbenzenesulfonothioate 
• 244768-86-3 o-methylbenzenesulfonyl bromide 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 52140-38-2 1-(benzylsulfonyl)-2-methylbenzene 
• 23276-69-9 1-methyl-2-(methylsulfonyl)benzene 
• 1858-84-0 2-methyl benzene sulfinic acid ethyl ester 
• 163883-28-1 1-phenyl-2-(o-tolylsulfonyl)ethan-1-one 
• 537684-22-3 2-o-tolyl-1H-indole 
• 101041-40-1 2-(4'-Methylphenyl)-thiomethyl-2,3-dihydrobenzofuran 
• 94626-19-4 2-methylbenzenesulfinic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of ketones by palladium-catalysed desulfitative reaction of arylsulfinic acids with nitriles

Palladium-catalysed desulfitative addition of arylsulfinic acids to aryl and alkyl nitriles with 2,2′-bipyridine as a ligand afforded a variety of aryl ketones via hydrolysis of ketimine intermediates.

Synergistic combination of visible-light photo-catalytic electron and energy transfer facilitating multicomponent synthesis of β-functionalized α,α-diarylethylamines

A synthetic strategy with the visible-light photo-catalytic synergistic combination of electron and energy transfer processes has been developed. The mild reaction conditions allow the radical-radical cross-coupling phenomenon for the multicomponent synthesis of β-arylsulfonyl(diarylphosphinoyl)-α,α-diarylethyl-amines from readily available arylsulfinic acids (diarylphosphine oxides), 1,1-diarylethylenes and arylazides.

Tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids

tert-Butyl nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-butyl nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.

Microwave-accelerated Pd-catalyzed desulfitative direct C2-arylation of free (NH)-indoles with arylsulfinic acids

The rapid and efficient direct C2-arylation of free (NH)-indoles with arylsulfinic acids proceeded through a microwave-accelerated palladium-catalyzed desulfitation reaction. By using PdCl2 as a catalyst, silver acetate as an oxidant, and H2SO4 as an additive, arylsulfinic acids with both electron-donating and electron-withdrawing groups underwent desulfitative coupling with an array of free (NH)-indoles, thereby selectively providing C2-arylindoles in good yields. From C2 shining sea: The direct C2-arylation of free (NH)-indoles with arylsulfinic acids proceeded through a Pd-catalyzed desulfitation reaction. In the presence of an oxidant and an additive, 2-arylindoles were selectively afforded in good yields. Copyright

Process for removal of allyl group or allyloxycarbonyl group

This invention relates to a process for the removal of an allyl or allyloxycarbonyl group from an allyl or allyloxycarbonyl group protected compound (such as an allylic ester, carbonate, carbamate, O-allyl derivatives or N-allyl derivatives), which comprises contacting the allyl or allyloxycarbonyl group protected compound with a sulfinic acid compound, in the presence of a palladium catalyst in a reaction-inert solvent. Preferably, the sulfinic acid compound is represented by the formula: wherein X is C1-20 alkyl, substituted C1-20 alkyl (wherein the substituent(s) are independently halo, nitro, sulfo, oxo, amino, cyano, carboxy, hydroxy or moieties derived therefrom), phenyl, substituted phenyl (wherein the substituent(s) are independently C1-3 alkyl, halo nitro, sulfo, oxo, amino, cyano, carboxy, hydroxy, acetamido or moieties derived therefrom), furyl or thienyl; and M is hydrogen, an alkali metal or ammonium salt residue. Of these, most preferred sulfinic acid compound is lithium p-toluenesulfinate, sodium p-toluenesulfinate, potassium p-toluenesulfinate, p-toluenesulfinic acid, ammonium p-toluenesulfinate, lithium benzenesulfinate, sodium benzenesulfinate, potassium benzenesulfinate, benzenesulfinic acid or ammonium benzenesulfinate. This invention is well suited to a process for the conversion of an allyl ester of 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid to 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid.