131653-66-2Relevant academic research and scientific papers
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries
Ferraris, Dana,Ko, Yao-Sen,Pahutski, Thomas,Ficco, Rica Pargas,Serdyuk, Larisa,Alemu, Christina,Bradford, Chadwick,Chiou, Tiffany,Hoover, Randall,Huang, Shirley,Lautar, Susan,Liang, Shi,Lin, Qian,Lu, May X.-C.,Mooney, Maria,Morgan, Lisa,Qian, Yongzhen,Tran, Scott,Williams, Lawrence R.,Wu, Qi Yi,Zhang, Jie,Zou, Yinong,Kalish, Vincent
, p. 3138 - 3151 (2007/10/03)
A series of aza-5[H]-phenanthridin-6-ones were synthesized and evaluated as inhibitors of poly ADP-ribose polymerase-1 (PARP-1). Inhibitory potency of the unsubstituted aza-5[H]-phenanthridin-6-ones (i.e., benzonaphthyridones) was dependent on the positio
Compounds and their use
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, (2008/06/13)
This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
Synthesis of 3-Amino-4-phenylpyridines: a Novel Strategy for the Preparation of CD Ring Models of Streptonigrin
Marsais, Francis,Rovera, Jean-Claude,Turck, Alain,Godard, Alain,Queguiner, Guy
, p. 2611 - 2612 (2007/10/02)
An efficient synthesis of 3-amino-4-phenylpyridine derivatives is reported. 3-Pivaloylaminopyridines were lithiated by butyl-lithium before reaction with iodine as electrophile to afford 4-iodo-3-pivaloylaminopyridines.Cross-coupling of the latter with su
