131656-82-1

Basic information

• Product Name: ((4-hydroxy-3-methoxyphenyl)acetyl)pyrrolidine
• Synonyms: ((4-hydroxy-3-methoxyphenyl)acetyl)pyrrolidine
• CAS NO: 131656-82-1
• Molecular Weight: 235.283
• Mol File: 131656-82-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ((4-hydroxy-3-methoxyphenyl)acetyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: ((4-hydroxy-3-methoxyphenyl)acetyl)pyrrolidine(131656-82-1)
• EPA Substance Registry System: ((4-hydroxy-3-methoxyphenyl)acetyl)pyrrolidine(131656-82-1)

Safety Data

• Hazardous Substances Data: 131656-82-1(Hazardous Substances Data)

Upstream product

• 4468-59-1 4-hydroxy-3-methoxyphenylacetonitrile 
• 498-00-0 4-hydroxymethyl-2-methoxyphenol 
• 123-75-1 pyrrolidine 
• 306-08-1 Homovanillic acid 

Downstream Products

• 131656-83-2 ((3-methoxy-4-(pivaloyloxy)phenyl)acetyl)pyrrolidine 
• 131656-89-8 2-methoxy-N-((3-methoxy-4-(pivaloyloxy)phenyl)acetyl)pyrrolidine 

Relevant articles and documents

Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide

Sixteen derivatives of N-acetyl-3-O-methyldopamine (NAMDA), an inhibitor of BH4 synthesis, were designed and synthesized. The ability of these derivatives to inhibit NO and BH4 production by lipopolysaccharide- stimulated BV-2 microglial cells was determined. While NAMDA at 100 μM inhibited NO and BH4 production by only about 20%, its catecholamide 8, indole 23 derivative, 13, and N-acetyl tetrahydroisoquinoline 25 inhibited the NO production by >50% at the same concentration. In particular, 13 and 25 inhibited both NO and BH4 production to similar degrees, which suggested that these compounds might inhibit NO production by blocking BH 4-dependent dimerization of the newly synthesized iNOS monomer.