1316759-06-4Relevant academic research and scientific papers
Selective non zinc binding inhibitors of MMP13
Savi, Chris De,Morley, Andrew D.,Ting, Attilla,Nash, Ian,Karabelas, Kostas,Wood, Christine M.,James, Michael,Norris, Stephen J.,Karoutchi, Galith,Rankine, Neil,Hamlin, Gordon,MacFaul, Philip A.,Ryan, David,Baker, Sarah V.,Hargreaves, David,Gerhardt, Stefan
, p. 4215 - 4219 (2011/08/06)
Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.
