21120-68-3

Usage

Uses

Used in Pharmaceutical Research and Development:
4-(4-BROMOPHENOXY)BENZOIC ACID 97 is used as a key component in the research and development of pharmaceuticals for its potential therapeutic properties and ability to be synthesized into various drug molecules.
Used in Agrochemical Manufacturing:
In the agrochemical industry, 4-(4-BROMOPHENOXY)BENZOIC ACID 97 is used as a vital ingredient in the production of pesticides and other agricultural chemicals, contributing to enhanced crop protection and yield.
Used as an Intermediate in Organic Synthesis:
4-(4-BROMOPHENOXY)BENZOIC ACID 97 serves as an intermediate in organic synthesis, allowing for the creation of a wide range of organic compounds for various applications, including the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Dye and Pigment Production:
4-(4-BROMOPHENOXY)BENZOIC ACID 97 is utilized in the production of dyes and pigments, providing colorants for various industries such as textiles, plastics, and printing inks.
Used in Chemical Research:
4-(4-BROMOPHENOXY)BENZOIC ACID 97 is employed in chemical research to study its properties and potential applications, further expanding its use in various fields and industries.

InChI:InChI=1/C13H9BrO3/c14-10-3-7-12(8-4-10)17-11-5-1-9(2-6-11)13(15)16/h1-8H,(H,15,16)

Upstream product

• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 2050-47-7 4,4'-dibromodiphenyl ether 
• 71-43-2 benzene 
• 106-41-2 4-bromo-phenol 
• 403-33-8 methyl 4-flurobenzoate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 21120-75-2 methyl 4-(4-bromophenoxy)benzoate 
• 1316759-02-0 C₂₈H₂₇N₃O₃ 
• 1316759-04-2 C₂₈H₂₇N₃O₃ 
• 1316759-06-4 C₂₈H₂₇N₃O₃ 
• 1316759-08-6 4-[4-[2-[(3S)-3-hydroxyquinuclidin-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide 
• 1316759-10-0 C₂₇H₂₆N₄O₃ 
• 1316759-12-2 C₂₇H₃₀N₄O₃ 
• 1316759-14-4 C₂₇H₂₈N₄O₃ 
• 1316759-16-6 C₂₈H₂₈N₄O₃ 
• 1316759-18-8 C₂₇H₂₆N₄O₂ 
• 1316759-34-8 C₂₃H₂₃NO₄ 
• 1316759-21-3 methyl 4-[4-[2-[(3S)-3-hydroxyquinuclidin-3-yl]ethynyl]phenoxy]benzoate 
• 1316759-32-6 C₂₃H₂₃NO₄ 
• 1316759-36-0 C₂₃H₂₅NO₄ 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS

This disclosure provides pharmaceutical compounds to treat medical disorders, such as complement-mediated disorders, including complement C1-mediated disorders.

Synthesis and structure–activity relationship of N-(piperidin-4-yl)benzamide derivatives as activators of hypoxia-inducible factor 1 pathways

Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13?μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.

Evaluation of Novel N-(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells

In this study, a series of novel N-(piperidine-4-yl)benzamide derivatives was designed, synthesized, and evaluated for antitumor activity. Some compounds were found to have potent antitumor activity. In particular, compound 47 showed the most potent biological activity against HepG2 cells, with an IC50 value of 0.25 μm. Western blot analysis demonstrated that compound 47 inhibited the expression of cyclin B1 and p-Rb and enhanced the expression of p21, p53, Rb, and phospho-adenosine monophosphate-activated protein kinase (p-AMPK). Further, cell cycle arrest was observed by flow cytometry (FCM). In summary, compound 47 was screened to have potential activity for the treatment of hepatocarcinoma via the induction of cell cycle arrest by a p53/p21-dependent pathway.

Synthesis of aromatic carboxylic acids by carbonylation of aryl halides in the presence of epoxide-modified cobalt carbonyls as catalysts

A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in a high yield under very mild conditions. Highly active catalytic systems, base-containing alcoholic solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides. 2005 Pleiades Publishing, Inc.