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1316759-09-7

1-methyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1316759-09-7 Structure

  • Basic information

    1. Product Name: 1-methyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester
    2. Synonyms: 1-methyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester
    3. CAS NO:1316759-09-7
    4. Molecular Formula:
    5. Molecular Weight: 289.334
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1316759-09-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-methyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-methyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester(1316759-09-7)
    11. EPA Substance Registry System: 1-methyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester(1316759-09-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1316759-09-7(Hazardous Substances Data)

1316759-09-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1316759-09-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,6,7,5 and 9 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1316759-09:
(9*1)+(8*3)+(7*1)+(6*6)+(5*7)+(4*5)+(3*9)+(2*0)+(1*9)=167
167 % 10 = 7
So 1316759-09-7 is a valid CAS Registry Number.

1316759-09-7Relevant articles and documents

Flexible synthesis of isomeric pyranoindolones and evaluation of cytotoxicity towards HeLa cells

Jeyaveeran,Praveen, Chandrasekar,Arun,Prince,Perumal

, p. 787 - 802 (2016/05/19)

A hybrid pharmacophore approach for the synthesis of isomeric pyranoindolones was achieved by employing gold(III) chloride-catalyzed cycloisomerization of alkyne-tethered indole carboxylic acids in good to excellent yield. All the synthesized compounds were evaluated for their tumor cell growth inhibitory activity against human cervix adenocarcinoma (HeLa) which revealed that three compounds exhibited activity comparable with the standard cis-platin (IC50 = 0.08 μM). Molecular docking of all the compounds in Vaccinia H1-Related (VHR) Phosphatase receptor also supported that compound 7d as the most active with a free energy of binding as ?8.27 kcal/mol. [Figure not available: see fulltext.]

Gold(III) chloride catalyzed regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones and evaluation of anticancer potential towards human cervix adenocarcinoma

Praveen, Chandrasekaran,Ayyanar, Asairajan,Perumal, Paramasivan Thirumalai

, p. 4170 - 4173 (2011/08/06)

A highly regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones via gold(III) chloride catalyzed cycloisomerization of 3-ethynyl-indole-2-carboxylic acid was achieved in good to excellent yields. These compounds were screened for their in vitro cytotoxicity against human cervical (HeLa) cell lines. Out of ten compounds, three compounds (7d, 7e and 7j) showed comparable proliferation inhibitory activity against the standard drug cisplatin. Compound 7d was found to be the most efficacious with IC50 value of 0.22 μM.

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