1316859-98-9

Upstream product

• 30095-98-8 methyl (2-nitrophenyl)acetate 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 

Downstream Products

• 1316859-97-8 1-(4-fluorobenzyl)-2-iodobenzene 
• 4888-33-9 4-phenyl-3,4-dihydro-1H-quinolin-2-one 
• 1039-51-6 2,4-diphenylquinoline 
• 343-40-8 3-fluoro-9H-fluorene 
• 779-77-1 2-(4-fluorobenzyl)aniline 
• 1316859-57-0 2-(2-nitrobenzyl)naphthalene 
• 1316859-52-5 1-(4-methoxybenzyl)-2-nitrobenzene 
• 886570-16-7 1-(4-fluorobenzyl)-2-nitrobenzene 
• 886570-18-9 3-(2-nitrobenzyl)benzonitrile 
• 1316859-64-9 methyl(3-(2-nitrobenzyl)phenyl)sulfane 
• 1316859-51-4 ethyl 4-(2-nitrobenzyl)benzoate 
• 1316859-66-1 ethyl 2-(4-(2-nitrobenzyl)phenyl)acetate 
• 1316859-54-7 N,N-dimethyl-4-(2-nitrobenzyl)aniline 
• 1316859-48-9 4-(2-nitrobenzyl)phenyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Enantioselective Total Syntheses of (-)-Rhazinilam, (-)-Leucomidine B, and (+)-Leuconodine F

A divergent total synthesis of three structurally distinct natural products from imine 9 was accomplished through an approach featuring: 1) a Pd-catalyzed decarboxylative cross-coupling, and 2) heteroannulation of 9 with bromoacetaldehyde and oxalyl chloride to give tetrahydroindolizine 6 and dioxopyrrole 7, respectively. The former was converted into (-)-rhazinilam, while the latter was converted into (-)-leucomidine B and (+)-leuconodine F. A substrate-directed highly diastereoselective reduction of a sterically unbiased double bond by using a homogeneous palladium catalyst was developed. A self-induced diastereomeric anisochronism (SIDA) phenomenon was observed for leucomidine B. Be divergent: Concise total syntheses of (-)-rhazinilam, (-)-leucomidine B, and (+)-leuconodine F were accomplished from the common intermediate A. A homogeneous palladium catalyst was exploited for the first time to accomplish a substrate-directed highly diastereoselective hydrogenation of a sterically unbiased double bond. A self-induced diastereomeric anisochronism (SIDA) phenomenon was observed for leucomidine B.

Unified strategy to monoterpene indole alkaloids: Total syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A

Total syntheses of (±)-goniomitine, (±)-1,2-dehydroaspidospermidine, (±)-aspidospermidine, (±)-vincadifformine, and (±)-kopsihainanine A were achieved featuring two common key steps: (1) a palladium-catalyzed decarboxylative vinylation that provides quick access to cyclopentene intermediates containing all of the carbons present in the natural products and (2) an integrated oxidation/reduction/cyclization (iORC) sequence for skeletal reorganization that converts the cyclopentenes to the pentacyclic structures of the natural products. By incorporation of a geometric constraint to iORC substrates, both the chemoselectivity (C7 vs N1 cyclization) and the stereoselectivity (trans- vs cis-fused ring system) of the cyclization process can be controlled.

Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: Application to the total synthesis of (±)-goniomitine

Merge and divert: The natural product (±)-goniomitine was synthesized by a method featuring two key steps: 1) fragment coupling to a functionalized cyclopentene by a novel palladium-catalyzed decarboxylative vinylation reaction and 2) an unprecedented one-pot integrated oxidation/reduction/cyclization (IORC) process to convert the substituted cyclopentene into the tetracyclic skeleton of goniomitine with high chemo-, regio-, and diastereoselectivity.

Palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates with aryl halides

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes and their derivatives.