131699-30-4Relevant academic research and scientific papers
A novel lanthanum metal-assisted reaction of diaryl ketones and electrophiles
Umeda, Rui,Ninomiya, Masashi,Nishino, Toshiaki,Kishida, Makoto,Toiya, Shunsuke,Saito, Tomoki,Nishiyama, Yutaka,Sonoda, Noboru
, p. 1287 - 1291 (2015/03/05)
A novel and efficient lanthanum metal-assisted carbon-carbon bond formation of diaryl ketones and various electrophiles, such as carbonyl compounds, esters, nitriles, and epoxides, has been developed. When diaryl ketones were allowed to react with dialkyl ketones in the presence of lanthanum metal and a catalytic amount of iodine, the cross pinacol coupling reaction proceeded to give the corresponding unsymmetrical 1,2-diols in moderate to good yields. α-Hydroxy ketones were prepared by the lanthanum metal-assisted reaction of diaryl ketones with esters or nitriles, followed by hydrolysis with aq HCl. It is interesting to note that for the epoxides, the coupling reaction proceeded via the Meinwald rearrangement of epoxides to give the corresponding 1,2-diols.
Titanium-mediated cross-coupling reactions of imines with ketones or aldehydes: An efficient route for the synthesis of 1,2-amino alcohols
Fan, Guoqin,Liu, Yuanhong
supporting information; experimental part, p. 5084 - 5087 (2012/09/25)
The cross-coupling reactions of imines with ketones using Ti(O iPr)4/c-C5H9MgCl reagent lead to 1,2-amino alcohols after hydrolysis. The coupling reactions with aldehydes could also afford 1,2-amino alcohols, however, in some cases, aziridines were obtained as major products in a stereoselective manner.
Nucleophilic substitution reactions of aminoalkylbenzotriazoles with ytterbium metal umpoled diaryl ketones
Su, Weike,Yang, Bibo,Zhang, Yongmin
, p. 2251 - 2253 (2007/10/03)
The reaction of diaryl ketones such as benzophenone with aminoalkylbenzotriazoles in the presence of ytterbium metal at room temperature has been found to give 2-amino alcohols in good yields under mild and neutral conditions.
Samarium (ii) iodide promoted reductive coupling of ketones and imines
Ma,Zhang,Zhou
, p. 250 - 251 (2007/10/03)
The cross-coupling reactions of imines with aromatic ketones induced by Sml2/THF system were studied; 2-amino alcohols are prepared in good yields under refluxing conditions.
