131699-70-2

Upstream product

• 4116-39-6 1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-6-carbonsaeuremethylester 
• 131699-68-8 1,3-Dimethyl-6-[2-((R)-toluene-4-sulfinyl)-acetyl]-1H-pyrimidine-2,4-dione 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 131699-69-9 6-[(S)-1-Hydroxy-2-((R)-toluene-4-sulfinyl)-ethyl]-1,3-dimethyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 131699-67-7 (+)-(S)-6-Oxiranyl-1,3-dimethyl-pyrimidin-2,4-dione 

Relevant academic research and scientific papers

Researches on antiviral agents. 3. Synthesis and transformations of racemic and chiral 6-oxiranyl pyrimidinones

The synthesis of epoxides 3, 4 and 6 has been described. The transformation of 3 into C-6 alkylated uracils 22a-e, 23a-d, 24 and 25 is also reported. The chiral epoxide (S)-(+)-3 has been prepared via a modified Solladie procedure, while the ZnCl2- DIBAH reduction step failed to give the expected enantiomer (R)-(-)-3. This result has been discussed on the ground of molecular modeling studies.

RESEARCHES ON ANTIVIRAL AGENTS. 2. ENANTIOSPECIFIC SYNTHESIS OF 1,3-DIMETHYL-6-OXIRANYLPYRIMIDIN-2,4-DIONE WITH ANTI-ASFV ACTIVITY.

Chiral epoxide (+)2 has been synthetized in very good yield and high enantiomeric excess via a modified Solladie procedure starting from commercially available orotic acid.Chiral HPLC chromatographic analysis and 300 MHz 1H-NMR with the addition of chiral shift reagent Eu(hfc)3 of compound (+)2 are also reported.