131699-67-7

Usage

Type of Compound

Pharmaceutical compound

Activity

Potential antitumor activity

Nature

Synthetic compound

Mechanism of Action

Inhibits various enzymatic pathways involved in cell proliferation and survival

Target Enzyme

Thymidylate synthase

Role of Target Enzyme

Essential for DNA synthesis

Potential Applications

Treatment of various types of cancer, including colorectal and lung cancer

Molecular Structure

Unique molecular structure

Field of Research

Oncology

Current Status

Promising candidate for further research and development in cancer treatment

InChI:InChI=1/C8H10N2O3/c1-9-5(6-4-13-6)3-7(11)10(2)8(9)12/h3,6H,4H2,1-2H3

Upstream product

• 4116-39-6 1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-6-carbonsaeuremethylester 
• 131699-70-2 6-((S)-1-Hydroxy-2-p-tolylsulfanyl-ethyl)-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 74-88-4 methyl iodide 
• 131699-69-9 6-[(S)-1-Hydroxy-2-((R)-toluene-4-sulfinyl)-ethyl]-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 131699-68-8 1,3-Dimethyl-6-[2-((R)-toluene-4-sulfinyl)-acetyl]-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Researches on antiviral agents. 3. Synthesis and transformations of racemic and chiral 6-oxiranyl pyrimidinones

The synthesis of epoxides 3, 4 and 6 has been described. The transformation of 3 into C-6 alkylated uracils 22a-e, 23a-d, 24 and 25 is also reported. The chiral epoxide (S)-(+)-3 has been prepared via a modified Solladie procedure, while the ZnCl2- DIBAH reduction step failed to give the expected enantiomer (R)-(-)-3. This result has been discussed on the ground of molecular modeling studies.

RESEARCHES ON ANTIVIRAL AGENTS. 2. ENANTIOSPECIFIC SYNTHESIS OF 1,3-DIMETHYL-6-OXIRANYLPYRIMIDIN-2,4-DIONE WITH ANTI-ASFV ACTIVITY.

Chiral epoxide (+)2 has been synthetized in very good yield and high enantiomeric excess via a modified Solladie procedure starting from commercially available orotic acid.Chiral HPLC chromatographic analysis and 300 MHz 1H-NMR with the addition of chiral shift reagent Eu(hfc)3 of compound (+)2 are also reported.