131700-41-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 130697-60-8 (1'R,2R,2'S,4aR,7R,8aR)-2-<2'-(t-butyldimethylsiloxy)cyclobutyl>-4a,5,6,7,8,8a-hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiine 
• 130697-58-4 (2S,2'R,4a'R,7'R,8a'R)-2-(4a',5',6',7',8',8a'-hexahydro-4',4',7'-trimethyl-4'H-1',3'-benzoxathiin-2'-yl)cyclobutanone 
• 130632-75-6 (2R,2'R,4a'R,7'R,8a'R)-2-(4a',5',6',7',8',8a'-hexahydro-4',4',7'-trimethyl-4'H-1',3'-benzoxathiin-2'-yl)cyclobutanone 
• 130697-59-5 (1S,2R,2'R,4a'R,7'R,8a'R)-2-(4a',5',6',7',8',8a'-hexahydro-4',4',7'-trimethyl-4'H-1',3'-benzoxathiin-2'-yl)cyclobutanol 
• 130697-61-9 (1R,2S)-2-(t-butyldimethylsiloxy)cyclobutanecarboxaldehyde 
• 131726-60-8 (1S,2S)-2-(t-butyldimethylsiloxy)cyclobutylmethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 130632-77-8 (1'R,2R,2'R,4aR,7R,8aR)-2-<2'-(t-butyldimethylsiloxy)cyclobutyl>-4a,5,6,7,8,8a-hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiine 
• 130632-76-7 (1R,2R,2'R,4a'R,7'R,8a'R)-2-(4a',5',6',7',8',8a'-hexahydro-4',4',7'-trimethyl-4'H-1',3'-benzoxathiin-2'-yl)cyclobutanol 
• 130632-78-9 (1R,2R)-2-(t-butyldimethylsiloxy)cyclobutanecarboxaldehyde 
• 131700-40-8 (1S,2R)-2-(t-butyldimethylsiloxy)cyclobutylmethanol 

Relevant academic research and scientific papers

Ring Expansion of Cyclopropylmethanols to Cyclobutanes - An Enantioselective Total Synthesis of (R)-(+)-Dodecan-5-olide, and (S)-(+)- and (R)-(-)-5-dihydrofuran-2(3H)-one

A novel and convenient route to chiral cyclobutanones (8) and (9) by ring expansion of the cyclopropylmethanols (6) and (7) was developed, leading to an enantioselective total synthesis of (R)-(+)-dodecan-5-olide (25), and (S)-(+)- and (R)-(-)-5-dihydrofuran-2(3H)-one (35) and (36) (the pheromone of the Japanese beetle).