131701-86-5

Upstream product

• 57392-44-6 2,2,2-trichloroethyl butyrate 
• 105363-56-2 (3-hydroxy)butyl p-tolyl sulfone 
• 61476-94-6 4-[(4'-methylphenyl)sulfonyl]-2-butanone 
• 3185-99-7 Methyl p-tolyl sulfone 
• 16088-62-3 (S)-Propylene oxide 
• 167934-61-4 (E)-(S)-4-Methylsulfanyl-4-(toluene-4-sulfonyl)-but-3-en-2-ol 

Downstream Products

• 155729-09-2 (S)-Ethyl 1-methyl-3-(p-tolylsulfonyl)propyl succinate 
• 131701-90-1 (S)-6-Methyl-4-(toluene-4-sulfonyl)-tetrahydro-pyran-2-one 
• 155729-07-0 (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate 
• 155729-10-5 Ethyl (S)-1-Methyl-3-(p-tolylsulfonyl)propyl oxalate 

Relevant academic research and scientific papers

Highly stereoselective radical addition to 3-Hydroxy-1-(methylthio)-1-(p-tolylsulfonyl)-1-alkanes and its application to the preparation of optically active compounds

Efficient 1,2-asymmetric induction was realized in the addition of a 1-hydroxyalkyl radical (R2C-OH to 3-hydroxy-1-methylthio)-1-(p-tolylsulfonyl)-1-alkenes and their acetates (1): Irradiation of 1 and benzophenone in an alcohol (R2CHOH) gave a

Facile Intramolecular Acylation Reactions of γ- and δ-(Acyloxy)Sulfones: Synthesis of Substituted Chiral Dihydrofurans and Dihydropyrans

The acylation of (S)-4-(p-tolylsulfonyl)-2-butanol and (S)-(p-tolylsulfonyl)-3-pentanol, chirons that are available in high optical purities, with a variety of acid chlorides gave the corresponding derivatives 9-16.Deprotonation of these substrates with L

Synthesis of (S)-(+)-parasorbic acid and (S)-(+)-2-tridecanol acetate: Bakers' yeast reductions of γ and δ ketosulfones

The enantioselective reduction of 4-(p-toluenesulfonyl) butane-2-one and 5-(p-toluenesulfonyl) pentane-2-one with bakers' yeast gave the corresponding (S) alcohols in high optical purities and moderately good yields. The alcohol 2a was converted to (S)(+)parasorbic acid (4), while 2b was used for the preparation of (S)(+)-2-tridecanol acetate (7), using short synthetic sequences.

LIPASE-CATALYSED RESOLUTION OF HYDROXY SULFONES

Porcine pancreatic lipase catalyses the enantioselective transesterification of β-, γ, and δ-hydroxy sulfones with 2,2,2-trichloroethyl butyrate in ethyl ether.