131742-16-0

Basic information

• Product Name: 4-[bis(4-fluorophenyl)methylene]-1-(2-hydroxyethyl)piperidine
• Synonyms: 4-[bis(4-fluorophenyl)methylene]-1-(2-hydroxyethyl)piperidine
• CAS NO: 131742-16-0
• Molecular Weight: 329.39
• Mol File: 131742-16-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[bis(4-fluorophenyl)methylene]-1-(2-hydroxyethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[bis(4-fluorophenyl)methylene]-1-(2-hydroxyethyl)piperidine(131742-16-0)
• EPA Substance Registry System: 4-[bis(4-fluorophenyl)methylene]-1-(2-hydroxyethyl)piperidine(131742-16-0)

Safety Data

• Hazardous Substances Data: 131742-16-0(Hazardous Substances Data)

Upstream product

• 624-76-0 Iodoethanol 
• 58113-36-3 4-(bis(4-fluorophenyl)methylene)piperidine 
• 58113-23-8 4-[bis-(4-fluorophenyl)-methylene]-piperidine hydrochloride salt 

Downstream Products

• 133364-79-1 3-[2-[4-[Bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]-2H-thiazolo-[3.2-a]-1,3,5-triazine-2,4(3H)-dione Hydrochloride 
• 131741-82-7 4-[Bis-(4-fluoro-phenyl)-methylene]-1-(2-chloro-ethyl)-piperidine 
• 133365-29-4 3-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-6,7,8,9-tetrahydro-pyrido[1,2-a][1,3,5]triazine-2,4-dione 
• 133364-77-9 3-[2-[4-[Bis(4-fluorophenyl)-methylene]piperidin-1-yl]ethyl]-7,8-dihydro-2H,6H,pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione 
• 137541-00-5 3-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-thiazolo[3,2-a][1,3,5]triazine-2,4-dione 

Relevant articles and documents

Simplified analogues of ritanserin and their affinity at 5-HT(2A), 5- HT(2B) and 5-HT(2C) serotonin receptors

The 5-HT2 serotonin antagonist ritanserin (6-(2-[4-[bis(4- fluorophenyl)methylene]-l-piperidinyl]ethyl)-7-methyl-5H-thiazole[3,2- a]pyrimidin-5-one, 2) binds with high affinity to 5-HT(2A), 5-HT(2B) and 5- HT(2C) serotonin receptors. With the aim of exploring how simplification of the thiazolepyrimidinone nucleus of 2 affects the affinity and selectivity for 5-HT(2A), 5-HT(2B) and 5-HT(2C) subtypes, some derivatives of 4-[bis(4- fluorophenyl)methylene]piperidine were synthesized, and their 5-HT(2A) and 5- HT(2C) receptor binding affinities and 5-HT(2B) antagonistic affinity evaluated. The new compounds bind the three 5-HT2 subtypes with lower affinity than did 2. Simplification of the thiazolepyrimidinone nucleus of ritanserin has only slight influence on the selectivity for 5-HT2 subtypes. The results suggest that the thiazolepyrimidinone moiety participates in key binding interactions and is determinant for high affinity at 5-HT2 receptor subtypes. Some derivatives showed antagonistic activity at 5-HT(2A) receptor.