131745-58-9

Upstream product

• 5467-72-1 α-amino-4-bromoacetophenone hydrochloride 
• 17630-76-1 5-chloroindole 2,3-dione 

Downstream Products

• 936024-66-7 5-(4-bromophenyl)-9-chloro-3-(4-chlorophenyl)-1H-[1,3]oxazino[4,5-c]quinolin-1-one 
• 936024-65-6 5-(4-bromophenyl)-9-chloro-3-phenyl-1H-[1,3]oxazino[4,5-c]quinolin-1-one 

Relevant academic research and scientific papers

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase

Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to diabetes secondary

Synthesis, in-vitro cytotoxicity, and a preliminary structure-activity relationship investigation of pyrimido[4,5-c]quinolin-1(2H)-ones

As part of our ongoing research effort to develop new antimitotic agents based on the recently reported pyrimido[4,5-c]quinoline-1(2H)-one ring skeleton, we were interested in identifying structural elements that contribute to the cytotoxicity of this cla

Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: Synthesis and in vitro cytotoxic activity

Several 2-amino-pyrimido[4,5-c]quinolin-1(2H)-ones variously substituted at positions 3, 5, and 9 were prepared from their corresponding lactones. The target compounds were investigated for in vitro cytotoxic activity against a panel of human cancer cell

Substituted quinolinecarboxylic acids

Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.