5467-72-1

Basic information

• Product Name: 2-AMINO-4'-BROMOACETOPHENONE HYDROCHLORIDE
• Synonyms: 2-amino-1-(4-bromophenyl)ethanone hydrochloride;2-Amino-4'-bromoacetophenone HCl;alpha-Amino-p-bromoacetophenone hydrochloride;N-p-Bromophenacylamine hydrochloride;2-Amino-4zzhlxy-bromoacetophenone hydrochloride96%;2-Amino-4'-bromoacetophenone hydrochloride, 2-Amino-1-(4-bromophenyl)ethan-1-one hydrochloride;Ethanone,2-aMino-1-(4-broMophenyl)-, hydrochloride (1:1);2-Amino-4'-bromoacetophenone hydrochloride 96%
• CAS NO: 5467-72-1
• Molecular Formula: C₈H₈BrNO*ClH
• Molecular Weight: 250.52
• EINECS: 226-778-3
• Product Categories: Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 5467-72-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 285 °C (dec.)(lit.)
• Boiling Point: 322.8 °C at 760 mmHg
• Flash Point: 149 °C
• Appearance: /
• Density: 1.52g/cm³
• Vapor Pressure: 0.000272mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• BRN: 3630035
• CAS DataBase Reference: 2-AMINO-4'-BROMOACETOPHENONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4'-BROMOACETOPHENONE HYDROCHLORIDE(5467-72-1)
• EPA Substance Registry System: 2-AMINO-4'-BROMOACETOPHENONE HYDROCHLORIDE(5467-72-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: AM5840000
• HazardClass: IRRITANT
• Hazardous Substances Data: 5467-72-1(Hazardous Substances Data)

Usage

Uses

2-Amino-4''-bromoacetophenone Hydrochloride is used as a reagent in the synthesis of Ledipasvir (L320100); a potent, once-daily oral NS5A inhibitor used for treatment of hepatitis C virus infection. 2-Amino-4''-bromoacetophenone Hydrochloride is also used in the preparation of the β-receptor agonists (-)-Denopamine (D231485) and (-)-Arbutamine (A766300).

General Description

2-Amino-4′-bromoacetophenone hydrochloride is an organic building block useful for chemical synthesis.

InChI:InChI=1/C8H8BrNO/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4H,5,10H2

Upstream product

• 49615-87-4 2-(4-bromophenyl)-2-oxoacetaldehyde oxime 
• 7644-04-4 4-bromophenacylamine 
• 127118-88-1 C₁₀H₈BrNO₃ 
• 6200-09-5 (4-bromo-phenacyl)-hexamethylenetetraminium; bromide 
• 18197-26-7 sodium diformamide 
• 99-73-0 para-bromophenacyl bromide 
• 99-90-1 para-bromoacetophenone 
• 71559-14-3 2-azido-1-(4-bromophenyl)ethanone 

Downstream Products

• 108275-73-6 N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiourea 
• 76477-12-8 N-(2-(4-bromophenyl)-2-oxoethyl)acetamide 
• 36018-05-0 N,N'-di(p-Bromophenacyl)terephthalamide 
• 55368-57-5 4-bromo-N-[2-(4-bromophenyl)-2-oxoethyl]benzamide 
• 181226-62-0 3-(4'-bromophenyl)-6,7,8,9-tetrahydro-5H-imidazo<1,2-a>azepine 
• 82221-15-6 N-(2-(4-bromophenyl)-2-oxoethyl)benzamide 
• 96908-21-3 2-phenyl-5-(4-bromophenyl)-5-oxazole 
• 96907-65-2 5-(4-bromophenyl)-2-(4-methylphenyl)oxazole 
• 118426-04-3 2-(4-nitrophenyl)-5-(4-bromophenyl)oxazole 
• 89752-95-4 4-[5-(4-Bromo-phenyl)-oxazol-2-yl]-phenylamine 
• 72571-04-1 ethyl [[2-(4-bromophenyl)-2-oxoethyl]amino]oxoacetate 
• 1154062-43-7 N-[2-(4-bromophenyl)-2-oxoethyl]-4-iodobenzoicamide 
• 1252645-53-6 3-amino-2-(4-bromophenyl)-6-methylquinoline-4-carboxylic acid 
• 1252645-50-3 3-amino-2-(4-bromophenyl)-6-iodoquinoline-4-carboxylic acid 

Relevant articles and documents

The reaction of prop-2-ynylsulfonium salts and sulfonyl-protected β-amino ketones to epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles

A novel divergent domino annulation reaction of prop-2-ynylsulfonium salts with sulfonyl-protected β-amino ketones has been developed, affording various epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles in moderate to excellent yields. Prop-2-ynylsulfonium salts act as C2synthons in the reactions providing a promising epoxide-fused skeleton in a single operation with readily accessible starting materials.

Monoglycosyl-containing heterocyclic compound for inhibiting hepatitis C viruses and preparation method

The invention discloses a monoglycosyl-containing heterocyclic compound for inhibiting hepatitis C viruses and a preparation method. The monoglycosyl-containing heterocyclic compound has a chemical structure represented by a formula I shown in the description. The monoglycosyl-containing heterocyclic compound disclosed by the invention can be used for effectively inhibiting protease of the hepatitis C viruses and treating infection of the hepatitis C viruses (HCV).

PH fluorescent probe by taking pyridine as protonizing site and application thereof

The invention relates to the technical field of detection, and particularly relates to a novel compound by using 4-(5-phenyl-2-oxazolyl)pyridine as a kernel structure as shown in the general formula (I), as well as a chemical preparation process of the pH fluorescent probe. According to the compound, R1, R2 and R3 are halogen atoms, nitrogen atoms, alkyl, alkoxy or group as shown in the formula IA, wherein Y is a group formed by covalent linkage of methylene, oxygen atom or nitrogen atom with a group as shown in a formula IB (in the formula IB, R5 is hydrogen atom, alkyl or alkoxy, Z1, Z2 and Z3 are null or oxygen atoms, and n, o and p are 0, 1 or 2; R4 represents hydrogen atom, methyl, methoxyl or a group as shown in the formula IB, and m is 0, 1 or 2; R1, R2 and R3 are not halogen atom, hydrogen atom, alkyl or alkoxy at the same time, and X is CH=CH or null, namely a biphenyl structure. The chemical preparation process is applied to fluorescent probe detection on pH value in an aqueous solution, fluorescent probe detection on the pH value in a cell, especially fluorenscense angiography of cells.