13177-70-3

Usage

Uses

Used in Medicinal Chemistry:
Furo[2,3-d]pyridazine, 4,7-dichloro is utilized as a key intermediate in the synthesis of pharmaceutical drugs. Its unique chemical structure allows for the development of new drug candidates with potential therapeutic effects.
Used in Industrial Synthesis:
Furo[2,3-d]pyridazine, 4,7-dichloro may serve as a building block or reactant in the synthesis of various industrial chemicals, contributing to the production of a wide range of products.
Used in Research:
Due to its unique chemical properties, Furo[2,3-d]pyridazine, 4,7-dichloro can be employed in research settings to explore its potential applications and investigate its interactions with other chemical compounds. This can lead to the discovery of new reactions, properties, and uses in various fields.

Upstream product

• 13379-61-8 furan-2,3-dicarboxylic acid dihydrazide 
• 488-93-7 3-Furoic acid 
• 37127-84-7 7-chloro-4-oxo-4,5-dihydrofuro[2,3-d]pyridazine-2-carboxylic acid 
• 37441-69-3 4,7-dichlorofuro[2,3-d]pyridazine-2-carboxylic acid 
• 52900-79-5 methyl 3-methoxycarbonylfuran-2-carboxylate 
• 13177-71-4 5,6-dihydrofuro[2,3-d]pyridazine-4,7-dione 
• 14757-85-8 7-chloro-5H-furo[2,3-d]pyridazin-4-one 
• 4282-24-0 furan-2,3-dicarboxylic acid 

Downstream Products

• 332013-40-8 4-chloroanilino-7-chlorofuro[2,3-d]pyridazine 
• 332013-41-9 4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine 
• 332012-57-4 4-[({4-[(3-chlorophenyl)amino]-furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide 
• 332012-40-5 Telatinib 
• 332012-41-6 4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine 
• 332012-46-1 4-[({4-[(4-methoxyphenyl)amino]furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide 
• 1057681-50-1 7-benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]furo[2,3-d]pyridazine 
• 1057681-53-4 4-benzyl-7-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]furo[2,3-d]pyridazine 
• 332013-51-1 4-(4-methoxyphenylamino)-7-chlorofuro-[2,3-d]pyridazine 
• 271-93-2 Furo<2,3-d>pyridazin 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY

Substituted pyridines and pyridazines having angiogenesis inhibiting activity and generalized structural formula (I) wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R and R may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermeability processes using these materials are also disclosed.

1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, that act via antagonism of the Smoothened receptor. A variety of analogues were synthesized and their structure-activity relationships determined. This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.

COMPOUNDS FOR TREATING PULMONARY HYPERTENSION

The present invention relates to pharmaceutical compositions and combinations for treating, preventing or managing pulmonary hypertension comprising small molecule heterocyclic pharmaceuticals, and more particularly, substituted pyridines and pyridazines optionally combined with at least one additional therapeutic agent.

Substituted pyridines and pyridazines with angiogenesis inhibiting activity

Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1and R2may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.