131773-47-2

Usage

Uses

Used in Pharmaceutical Industry:
2,6,7-TRICHLOROIMIDAZO[1,2-A]PYRIDINE is used as a building block in the synthesis of pharmaceuticals for its potential as an antitumor agent. It is valued in the development of bioactive compounds that can target and treat cancer cells.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6,7-TRICHLOROIMIDAZO[1,2-A]PYRIDINE serves as a key intermediate in the production of compounds with antimicrobial properties. This application is crucial for creating effective agents to combat microbial infections in agriculture.
Used in Materials Science:
2,6,7-TRICHLOROIMIDAZO[1,2-A]PYRIDINE is also utilized in the field of materials science. Its unique structure and properties make it a promising candidate for the development of new materials with specific characteristics, potentially useful in various technological applications.

Upstream product

• 105-36-2 ethyl bromoacetate 
• 188577-68-6 4,5-dichloro-2-aminopyridine 

Downstream Products

• 194228-60-9 3-iodo-2,6,7-trichloroimidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents

This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo[1,2-a]pyridine C-nucleosides, as exemplified by compounds such as imidazo[l,2-a]pyridine C5-nucleosides and imidazo[1,2-a]pyridine C3-nucleosides, and may be represented by formula (I), wherein exactly one of Q3and Q5is a sugar-like moiety; exactly one of Q3and Q5is —H; and Q2, Q6, Q7and Q8are independently imidazo[1,2-a]pyridine substituents, such as —H, —F, —Cl, —Br and —I.

An improved synthesis of 2-chlorinated imidazo[1,2-a]pyridines and the application of this procedure for the synthesis of several new polychlorinated imidazo[1,2-a]pyridines

Polychlorinated imidazo[1,2-a]pyridines were synthesized as analogs of certain chlorinated benzimidazoles. The imidazo[1,2-a]pyridines were obtained by a condensation of ethyl bromoacetate and chlorinated 2-aminopyridines. These condensation products were treated with an ion exchange resin to effect an exchange of hydrobromide salts with hydrochloride salts. These compounds were subsequently treated with POCl3 to convert the imidazo[1,2-a]pyridin-2-ones into 2-chloroimidazo[1,2-a]pyridines.