1318025-77-2

Usage

Uses

Used in Antimicrobial Applications:
Chevalone C is used as an antimicrobial agent for inhibiting the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium. It demonstrates its effectiveness in a disc diffusion assay when used at a concentration of 15 μg/disc.
Used in Anticancer Applications:
Chevalone C is used as an anticancer agent for inducing cell death in HCT116 colorectal carcinoma cells. It also shows cytotoxicity to BC1 human breast cancer cells with an IC50 value of 8.7 μg/ml.
Used in Antitubercular Applications:
Chevalone C is used as an antituberculous agent for inhibiting the growth of M. tuberculosis H37Ra with a minimum inhibitory concentration (MIC) of 6.3 μg/ml.

Relevant academic research and scientific papers

Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri

Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines.