1318128-40-3Relevant academic research and scientific papers
Access to optically active 3-aminopiperidines by ring expansion of prolinols: Thermodynamic versus kinetic control
Cochi, Anne,Pardo, Domingo Gomez,Cossy, Janine
experimental part, p. 2023 - 2040 (2012/05/20)
3-Aminopiperidines are of great interest because they can possess a wide range of biological activity depending on the nitrogen substituents. Different approaches their synthesis are presented and the most efficient is a ring expansion of prolinols induce
Access to optically active 3-azido- and 3-aminopiperidine derivatives by enantioselective ring expansion of prolinols
Cochi, Anne,Gomez Pardo, Domingo,Cossy, Janine
supporting information; experimental part, p. 4442 - 4445 (2011/10/05)
The activation of N-alkyl prolinols by XtalFluor E allowed the formation of an aziridinium intermediate that can react with tetrabutylammonium azide (nBu4NN3) to produce 3-azidopiperidines and/or 2-(azidomethyl)pyrrolidines, in a rat
