1318129-41-7

Upstream product

• 663948-84-3 tert-butyl [(3S,5S)-1-benzyl-5-(hydroxymethyl)pyrrolidin-3-yl]carbamate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 142292-37-3 (2S,4S)-(4-amino-1-benzylpyrrolidin-2-yl)methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51-35-4 4R-4-hydroxyproline 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 

Relevant academic research and scientific papers

INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS

Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.

Access to optically active 3-aminopiperidines by ring expansion of prolinols: Thermodynamic versus kinetic control

3-Aminopiperidines are of great interest because they can possess a wide range of biological activity depending on the nitrogen substituents. Different approaches their synthesis are presented and the most efficient is a ring expansion of prolinols induce

Access to optically active 3-azido- and 3-aminopiperidine derivatives by enantioselective ring expansion of prolinols

The activation of N-alkyl prolinols by XtalFluor E allowed the formation of an aziridinium intermediate that can react with tetrabutylammonium azide (nBu4NN3) to produce 3-azidopiperidines and/or 2-(azidomethyl)pyrrolidines, in a rat