13182-63-3Relevant academic research and scientific papers
RING OPENING OF 4-CHLOROQUINAZOLINE INTO 2-ARYLMETHYLENEAMINOBENZONITRILE BY GRIGNARD REACTION
Miyashita, Akira,Sasaki, Takami,Oishi, Etsuo,Higashino, Takeo
, p. 823 - 832 (2007/10/02)
The treatment of 4-chloroquinazoline (1) with arylmagnesium bromide (3) in tetrahydrofuran (THF) resulted in the formation of 2-arylmethyleneaminobenzonitrile (2).Continued reaction of ring opening of 1 and subsequent hydrolysis of the products (2) afforded the corresponding arenecarbaldehydes (4).
