1318252-91-3Relevant academic research and scientific papers
Efficient one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-e][1, 4]thiazepine]dione via three-component reaction
Chen, Hui,Shi, Daqing
, p. 5686 - 5692 (2011)
An efficient one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-e] [1,4]thiazepine] dione derivatives via three-component reaction of 5-amino-3-methylpyrazole, isatin, and thioacid is described. This new protocol produces novel heptacyclic spirooxindole derivatives in good yields in comparison to conventional pentacyclic compounds. This method proceeds through a 3-(5-aminopyrazol-3-yl)-3-hydroxy-2-oxindoline intermediate (Baylis-Hillman type adduct), unlike 3-indolylimine (the intermediate like Shiff-Bases) as in conventional methods. The structure of one representative compound has been confirmed by X-ray diffraction analysis.
