1318571-16-2Relevant academic research and scientific papers
Thiourea/proline derivative-catalyzed synthesis of tetrahydrofuran derivatives: A mechanistic view
Opalka, Suzanne M.,Steinbacher, Jeremy L.,Lambiris, Brandon A.,McQuade, D. Tyler
, p. 6503 - 6517 (2011)
A thiourea/proline derivative-catalyzed synthesis of linear α-substituted tetrahydrofuran/pyran derivatives starting with lactol substrates is presented. This study demonstrates the utility and potential complications of using (thio)urea/proline cocatalysis as each of these catalysts is necessary to provide the observed reactivity, but a time-dependent decrease in enantioselectivity is observed. New mechanistic insights into (thio)urea/proline cocatalysis are presented.
