1318759-59-9Relevant academic research and scientific papers
Palladium-catalyzed direct 2-alkylation of indoles by norbornene-mediated regioselective cascade C-H activation
Jiao, Lei,Bach, Thorsten
, p. 12990 - 12993 (2011)
A palladium-catalyzed direct 2-alkylation reaction of free N-H indoles has been developed. This reaction relies on a norbornene-mediated cascade C-H activation process at the indole ring, which features high regioselectivity and excellent functional group tolerance. The reaction represents the first example for a generally applicable, direct C-H alkylation of indole at the 2-position.
