1318779-88-2Relevant academic research and scientific papers
Quadruply hydrogen-bonded heteroduplexes based on imide and urea units arrayed with ADDA/DAAD sequences
Li, Xianghui,Jia, Yiming,Ren, Yi,Wang, Youjia,Hu, Jinchuan,Ma, Teng,Feng, Wen,Yuan, Lihua
, p. 6975 - 6983 (2013)
A new class of imide- and urea-based hetero-strands with a quadruple ADDA/DAAD hydrogen-bond array was designed and synthesized from easily accessible starting materials. The molecular recognition between the two different strands depends highly on the su
Folding and Assembly of Short α, β, ?-Hybrid Peptides: Minor Variations in Sequence and Drastic Differences in Higher-Level Structures
Zhang, Yukun,Zhong, Yulong,Connor, Alan L.,Miller, Daniel P.,Cao, Ruikai,Shen, Jie,Song, Bo,Baker, Erin S.,Tang, Quan,Pulavarti, Surya V.S.R.K.,Liu, Rui,Wang, Qiwei,Lu, Zhong-Lin,Szyperski, Thomas,Zeng, Huaqiang,Li, Xiaopeng,Smith, Richard D.,Zurek, Eva,Zhu, Jin,Gong, Bing
, p. 14239 - 14248 (2019/10/11)
Multilevel protein structures typically involve polypeptides of sufficient lengths. Here we report the folding and assembly of seven short tetrapeptides sharing the same types of α-, β-, and aromatic ?-amino acid residues. These are two sets of hybrid peptides, with three members in one set and four in the other, having complementary hydrogen-bonding sequences that were hypothesized to pair into linear H-bonded duplexes. However, instead of undergoing the anticipated pairing, the initially examined three oligomers, 1 and 2a or 2b, differing only in their central αβ hybrid dipeptide sequence, do not associate with each other and exhibit distinctly different folding behavior. Experiments based on NMR and mass spectrometry, along with computational studies and systematic inference, reveal that oligomer 1 folds into an expanded β-turn containing an unusual hybrid α/β-amino acid sequence composed of glycine and β-alanine, two α- A nd β-amino acid residues that are conformationally most flexible, and peptides 2a and 2b adopt a noncanonical, extended helical conformation and dimerize into double helices undergoing rapid conformational exchange or helix inversion. The different central dipeptide sequences, αβ vs βα, result in drastically different intramolecular H-bonding patterns that are responsible for the observed folding behavior of 1 and 2. The revealed turn and double helix have few natural or synthetic counterparts, and provide novel and unique folding prototypes based on which chiral α- A nd β-amino acids are incorporated. The resultant derivatives 1a, 1b, 2c, and 2d follow the same folding and assembling behavior and demonstrate the generality of this system with the formation of expanded β-turns and double helices with enhanced folding stabilities, hampered helix inversion, as well as defined and dominant helical sense. This work has demonstrated the unique capability of synthetic foldamers in generating structures with fascinating folding and assembling behavior. The revealed systems offer ample opportunity for further structural optimization and applications.
Convergent Ditopic Receptors Enhance Anion Binding upon Alkali Metal Complexation for Catalyzing the Ritter Reaction
Kang, Kang,Nagarajan, Sangaraiah,Chen, Lixi,Deng, Pengchi,Shen, Xin,Fu, Kuirong,Feng, Wen,Yuan, Lihua,Lohrman, Jessica A.,Johnson, Darren W.
, p. 652 - 655 (2019/04/10)
A supramolecular approach to catalyzing the Ritter reaction by utilizing enhanced anion-binding affinity in the presence of alkali metal cations was developed with ditopic hydrogen-bonded amide macrocycles. With prebound cations in the macrocycle, particu
Hydrogen-Bonded Duplexes with Lengthened Linkers
Zhang, Yukun,Cao, Ruikai,Shen, Jie,Detchou, Cadnel S. F.,Zhong, Yulong,Wang, Heng,Zou, Sheng,Huang, Qingfei,Lian, Chunxia,Wang, Qiwei,Zhu, Jin,Gong, Bing
, p. 1555 - 1558 (2018/03/23)
Connecting basic hydrogen-bonding units with lengthened flexible or rigid linkers generates oligoamide strands that carry new H-bonding sequences and association specificity, leading to H-bonded homo- and heteroduplexes with association constants in the 1
Convergent heteroditopic cyclo[6]aramides as macrocyclic ion-pair receptors for constructing [2]pseudorotaxanes
Hu, Jinchuan,Chen, Long,Shen, Jie,Luo, Jian,Deng, Pengchi,Ren, Yi,Zeng, Huaqiang,Feng, Wen,Yuan, Lihua
supporting information, p. 8024 - 8027 (2014/07/08)
A strategy of using amide groups as the only functionality was developed to construct convergent heteroditopic cyclo[6]aramides that are able to strongly bind dibutylammonium chloride in chloroform (>105 M-1), leading to the formation of [2]pseudorotaxanes. the Partner Organisations 2014.
Self-complementary quadruply hydrogen-bonded duplexes based on imide and urea units
Li, Xianghui,Fang, Yuyu,Deng, Pengchi,Hu, Jinchuan,Li, Tian,Feng, Wen,Yuan, Lihua
supporting information; experimental part, p. 4628 - 4631 (2011/11/06)
The quadruply hydrogen-bonded duplexes based on an imide-urea structure preorganized by three-center hydrogen bonds were found to associate via bifurcated hydrogen bonds. 1H NMR dilution experiments revealed the high stability of the homodimer in apolar solvent (Kdim > 10 5 M-1 in CDCl3) and enhancement of association ability due to electron-withdrawing substituent effects. The ready synthetic availability and adjustable association affinity via electronic effects may render these association units potentially applicable in constructing supramolecular architectures.
