13188-08-4Relevant academic research and scientific papers
α-Acylureidocephalosporins and salts and esters thereof
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, (2008/06/13)
Compounds which are clinically important cephalosporins and salts and esters thereof having a wide spectrum of activity against Gram-positive bacteria but especially against Gram-negative bacteria such as Pseudomonas spp. against which commercially available cephalosporins are normally inactive. Preferred compounds of the invention are also active against Gram-negative cephalosporinase-producing organisms such as Enterobacter spp., Serratia spp. and indole-positive Proteus; methods of preparation are described.
7-Ureido acetamido substituted cephalosporin antibiotics
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, (2008/06/13)
Cephalosporin antibiotics of the formula STR1 wherein R is STR2 and R" is H, C1 -C3 alkyl, allyl, propargyl, C3 -C6 cycloalkyl, phenyl, benzyl or furfuryl; R' is H or methyl; or R is a cyclic urea group for example, R is STR3 R1 is phenyl, thienyl, or furyl; R3 is a lower alkyl substituted 1H-tetrazole-5-thio or 1,3,4-thiadiazole-5-thio group and R4 is hydrogen or an active ester group, e.g., an acetoxymethyl group; are highly active broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms.
