13188-89-1

Basic information

• Product Name: H-D-ASP(OBZL)-OH
• Synonyms: H-D-ASP(OBZL)-OH;D-ASPARTIC ACID(OBZL)-OH;D-ASPARTIC ACID BETA-BENZYL ESTER;D-ASPARTIC ACID 4-BENZYL ESTER;D-ASPARTIC ACID-B-BENZYLESTER;(R)-2-Amino-4-(benzyloxy)-4-oxobutanoic acid;D-Asp(OBzl)-OH
• CAS NO: 13188-89-1
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• Mol File: 13188-89-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 413.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.283±0.06 g/cm3(Predicted)
• Storage Temp.: Store at 0°C
• PKA: 2.16±0.23(Predicted)
• CAS DataBase Reference: H-D-ASP(OBZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-ASP(OBZL)-OH(13188-89-1)
• EPA Substance Registry System: H-D-ASP(OBZL)-OH(13188-89-1)

Safety Data

• Hazardous Substances Data: 13188-89-1(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline

Uses

H-D-ASP(OBZL)-OH is a useful intermediate for the synthesis and studies of bacitracin and bacitracin analogs.

Upstream product

• 1783-96-6 (2R)-aspartic acid 
• 100-51-6 benzyl alcohol 
• 51186-58-4 4-benzyl Boc-D-aspartate 

Downstream Products

• 51186-58-4 4-benzyl Boc-D-aspartate 
• 46911-83-5 β-benzyl-D-aspartate-N-carboxyanhydride 
• 13590-42-6 β-benzyl-N-carboxy-DL-aspartate anhydride 
• 1166851-03-1 C₁₈H₁₉NO₆S 
• 1313202-21-9 C₁₇H₁₇NO₆S 
• 1313202-22-0 C₁₇H₁₆ClNO₆S 
• 1313202-28-6 C₁₉H₁₇ClN₂O₅S 
• 1313202-27-5 C₁₉H₁₈N₂O₅S 
• 1313202-23-1 C₂₂H₂₈N₂O₇S 
• 1313202-25-3 C₂₁H₂₅ClN₂O₇S 
• 1313202-24-2 C₂₁H₂₆N₂O₇S 
• 1313202-26-4 C₂₀H₂₀N₂O₅S 
• 1218935-69-3 C₁₇H₂₅NO₆Si 
• 150009-58-8 Fmoc-D-Asp(OBn)-OH 

Relevant articles and documents

Thermoresponsive Alignment Media in NMR Spectroscopy: Helix Reversal of a Copolyaspartate at Ambient Temperatures

Poly(aspartic acid esters) are known to form either right-or left-handed α-helices depending on the ester group in the side chain, on solvent and/or on temperature. Polyphenethyl-l-aspartates (PPLA) exhibit a helix reversal from the right- to the left-handed form with increasing temperature. We have recently reported the application of polyphenethylaspartates as helically chiral alignment media. The thermoresponsivity observed for these polymers offers the possibility to measure different orientations of analytes before and after helix reversal of the alignment medium at 373 K. Herein we present a synthesized copolymer of phenethyl- and benzylaspartate as a new alignment medium undergoing this helix reversal at 303–313 K. Thus, the measurement of residual dipolar couplings (RDC) before and after the helix reversal is allowed for at ambient temperatures. A complete sign change of all 1H–13C RDCs was observed, which is close to the highest possible difference in NMR spectra.

Process for the preparation of omega-benzyl esters of amino diacids and of alkanesulphonates of these esters, and these alkanesulphonates

The invention relates to a process for the preparation of an ?-benzyl ester of an amino diacid, characterized in that the amino diacid is reacted with a benzyl alcohol derivative of formula (I) 1 in which the R1 substituent or substituents, which are identical or different, represent a hydrogen atom, a C1 to C4 alkyl group, a C1 to C4 alkoxy group or a halogen atom and n is equal to 1, 2 or 3, in the presence of at least one mol per mole of the amino diacid of an alkanesulphonic acid, optionally in the presence of a solvent. The intermediate alkanesulphonates of the ?-benzyl esters of amino diacids and the ?-benzyl esters of amino diacids are obtained with a good yield and an excellent purity by virtue of this process.

Novel immunological adjuvant compounds and methods of preparation thereof

This application relates to novel immunological adjuvant compounds of the formula: STR1 wherein each of R and R1 are the same or different and are hydrogen or an acyl radical; R2 is an unsubstituted or substituted alkyl radical, or an unsubstituted or substituted aryl radical; R6 is an alkyl radical X is an aminoacyl moiety; and Y is D-isoasparagine or D-isoglutamine.