13190-75-5Relevant academic research and scientific papers
A Novel, One-Pot Ring Expansion of Cyclobutanones. Syntheses of Carbovir and Aristeromycin
Brown, Brian,Hegedus, Louis S.
, p. 1865 - 1872 (2007/10/03)
A novel, one-pot ring-expansion procedure was developed using Me3S(O)I, NaH, and Sc(OTf)3. The scope and limitations were briefly examined, and a tentative mechanism was proposed. Application of the methodology to known cyclobutanone 1 provided the corresponding cyclopentanone, which was successfully advanced to (+)-carbovir and (+)-aristeromycin.
A short and stereoselective synthesis of (±)-aristeromycin
Hutchison,Grim,Chen
, p. 451 - 452 (2007/10/02)
A new stereoselective three-step total synthesis of (±)-aristeromycin starting from readily available 1-hydroxymethyl-3-cyclopentene is described.
