131906-57-5Relevant academic research and scientific papers
Inhibitors of the interaction of a thyroid hormone receptor and coactivators: Preliminary structure-activity relationships
Arnold, Leggy A.,Kosinski, Aaron,Estébanez-Perpi?á, Eva,Fletterick, Robert J.,Guy, R. Kiplin
, p. 5269 - 5280 (2008/03/12)
The modulation of gene regulation by blocking the interaction between the thyroid receptor (TR) and obligate coregulators has been reported recently with the discovery of the lead compound 3-(dimethylamino)-1-(4-hexylphenyl)propan-1- one). Herein we repor
Synthesis of quaternary alkylammonium sulfobetaines
Ward, Robert S.,Davies, Joanna,Hodges, Geoffrey,Roberts, David W.
, p. 2431 - 2439 (2007/10/03)
A series of quaternary alkylammonium sulfobetaines of general formula RN+(CH3)2(CH2)nSO 3-, where n = 2-4, have been synthesised by reacting the corresponding N,N-dimethylamines with either sodium 2-chloroethanesulfonate (n = 2), 1,3-propane-sultone (n = 3), or 1,4-butanesultone (n = 4). Full details of the preparation of the required N,N-dimethylamines are reported.
Diels-Alder Reactions of a Surfactant 1,3-Diene
Jaeger, David A.,Shinozaki, Hiraku,Goodson, Patricia A.
, p. 2482 - 2489 (2007/10/02)
The ability of aqueous micelles and reversed micelles to control the regiochemistry of Diels-Alder reactions of (E,E)-6--1,3-butadienyl>amino>carbonyl>oxy>-N,N,N-trimethyl-1-hexanaminium bromide (4) and 1-(4-hexylphenyl)-2-propen-1-one (2b) was evaluated.If 2b and 4 were to react within the micelles in their preferred orientations, cycloadduct 10 would result, as opposed to 6--2-cyclohexen-1-yl>amino>carbonyl>oxy>-N,N,N-trimethyl-1-hexanaminium bromide (7b) and its exo isomer 8b, the theoretically predicted products actually obtained.The orientational effects in the aggregates were not strong enough to overcome the reaction's intrinsically preferred regiochemistry.
