131911-22-3Relevant academic research and scientific papers
S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase
Matsuno, Kenji,Takai, Kazushige,Isaka, Yoshinobu,Unno, Yuka,Sato, Masayuki,Takikawa, Osamu,Asai, Akira
supporting information; experimental part, p. 5126 - 5129 (2010/10/19)
S-Benzylisothiourea 3a was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit 3a lead to the identification of sub-μM inhibitors 3r and 10h, both of which suppressed kynurenine production in A431 cells. Synthesis and structure-activity relationship of S-benzylisothiourea analogues as small-molecule inhibitors of IDO are described.
