16793-91-2

Basic information

• Product Name: 2-CHLOROPHENETHYL BROMIDE
• Synonyms: Benzene, 1-(2-broMoethyl)-2-chloro-;2-Chlorophenethyl bromide 97%
• CAS NO: 16793-91-2
• Molecular Formula: C₈H₈BrCl
• Molecular Weight: 219.51
• Product Categories: Aryl;C8;Halogenated Hydrocarbons
• Mol File: 16793-91-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 110-112 °C10 mm Hg
• Flash Point: >230 °F
• Appearance: Colorless to yellow/Liquid
• Density: 1.4569 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0623mmHg at 25°C
• Refractive Index: n20/D 1.5707(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLOROPHENETHYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROPHENETHYL BROMIDE(16793-91-2)
• EPA Substance Registry System: 2-CHLOROPHENETHYL BROMIDE(16793-91-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-37/38-41-51/53
• Safety Statements: 26-39-61
• RIDADR: UN 3082 9 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 16793-91-2(Hazardous Substances Data)

Usage

General Description

2-Chlorophenethyl bromide is an organic compound that consists of a benzene ring with a chlorine atom and a bromine atom attached to it. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is also known for its application as a reagent in organic chemistry, particularly in the preparation of various types of compounds including ethers and esters. It is a colorless to pale yellow liquid that is volatile and has a strong, unpleasant odor. 2-Chlorophenethyl bromide is also known by its alternative name, 2-bromoethyl benzene, and has the chemical formula C8H8BrCl. It is important to handle this compound with caution as it is considered to be toxic and may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H8BrCl/c9-6-5-7-3-1-2-4-8(7)10/h1-4H,5-6H2

Upstream product

• 2444-36-2 2'-chloro-benzeneacetic acid 
• 2039-87-4 2-chlorostyrene 
• 19819-95-5 2-(2-chlorophenyl)-1-ethanol 

Downstream Products

• 96626-63-0 1-[2-(2-Chloro-phenyl)-ethyl]-4-(3-methoxy-phenyl)-3,3-dimethyl-4-phenyl-piperidine 
• 96626-49-2 1-[2-(2-Chloro-phenyl)-ethyl]-4-(3-methoxy-phenyl)-3,3,4-trimethyl-piperidine 
• 131911-22-3 S-(2-(2-chlorophenyl)ethyl)isothiourea hydrobromide 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 96129-64-5 2-chlorophenethyl azide 
• 96129-65-6 2-chloro-β-phenethylsulfonamide 
• 96129-63-4 2-chloro-β-phenethylsulfonyl azide 
• 129254-82-6 1-(2-chlorophenyl)-3-(pyridin-4-yl)butane 
• 129254-95-1 1-(2-chlorophenyl)-3-(3-ethyl-pyridin-4-yl)-propane 
• 938181-03-4 3-[2-(2-chlorophenyl)ethyl]-2-(2-methoxyphenyl)-5,6,7,8-tetrahydro-4(3H)-quinazolinone 
• 1043499-90-6 (2S,5R)-2-[2-(2-chlorophenyl)ethyl]-5-isopropyl-3,6-dimethoxy-2-methyl-2,5-dihydropyrazine 
• 1157077-96-7 4-(2-chlorophenethyl)morpholine 
• 1129277-48-0 C₉H₈ClNO₂ 
• 1261267-17-7 3-(2-chlorophenyl)-2-nitropropan-1-ol 

Relevant articles and documents

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Preparation method for hemihydrate lorcaserin hydrochloride

The invention discloses a preparation method for hemihydrate lorcaserin hydrochloride. The preparation method comprises the following steps: (1) making a compound shown as a formula III react with ammonia to obtain a compound shown as a formula II; (2) under the protection of nitrogen gas, dissolving the compound shown as the formula II in an organic solvent, adding a hydrogen chloride solution of which the solvent is the organic solvent to salify, and adding water and cyclohexane to form a hemihydrate in order to obtain the compound shown as a formula I, wherein the organic solvent is isopropanol or 1,4-dioxane. In the preparation method disclosed by the invention, ammonium hydroxide substitutes for potassium carbonate in the prior art, so that unqualified ignition residues of a finial product caused by potassium chloride generated after salt removal can be avoided; an isopropoxide hydrochloride solution substitutes for the conventional hydrogen chloride gas, so that other impurities can be prevented from being introduced in a preparation process under the improper control of dosage and rate of the gas.

Construction of chiral 2-substituted octahydroindoles from cyclic ketones and nitroolefins bearing only one α-substituent

A dual catalytic system has been developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitroolefins bearing only one α-substituent. The resulting γ-nitro ketones, which contain a substituent on the carbon connected to the nitro group, were formed in excellent yields (>80%) with high levels of stereoselectivity (up to 94:6 dr and 98% ee) when the reaction was performed in benzene at 0 °C with 10 mol% of the optimal amine/phosphoric acid combination (1:1) as a catalyst. Subsequent reduction of the nitro group followed by intramolecular reductive amination could afford optically active cis-octahydroindole analogues bearing a non-functional substituent at their 2-position.