1319197-07-3

Usage

Type of Compound

Synthetic indazole derivative

Receptor Interaction

Potent and selective agonist of the cannabinoid receptor CB2

Potential Applications

Treatment of various inflammatory and pain-related conditions

Animal Model Studies

Demonstrated promising results in reducing inflammation and pain

Advantages

Lacks psychoactive effects associated with traditional cannabinoid agonists

Therapeutic Applications

Being researched for conditions such as arthritis, neuropathic pain, and inflammatory diseases

Medication Development

Investigated for the development of novel medications for pain management and inflammation

Upstream product

• 623946-43-0 1-iodo-2-[(E)-2-nitrovinyl]benzene 
• 100-68-5 methyl-phenyl-thioether 
• 26260-02-6 2-iodobenzaldehyde 
• 5159-41-1 2-iodobenzyl alcohol 
• 88-67-5 2-Iodobenzoic acid 
• 271-44-3 benzimidazole 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 34602-69-2 1-(2'-aminophenyl)indazole 

Relevant academic research and scientific papers

N-Heterocycle-Stabilized Iodanes: From Structure to Reactivity

Pseudocyclic aryl-λ3-iodanes are superior reagents for a variety of oxidative transformations due to a well-balanced relation between stability, solubility and reactivity. Their properties are substantially influenced by a dative interaction between a Lewis base, in general the oxygen atom of a carboxylic acid or an amide, and the central hypervalent iodine atom. This work presents the first systematic investigation of pseudocyclic N-heterocycle-stabilized iodanes (NHIs). The synthesis of these throughout shelf-stable solids is robust and can be achieved on a large scale. Their reactivity is highly tunable, depending on the stabilizing heterocycle. Solid state structures of selected derivatives are reported and their reactivity in a model oxygen transfer reaction is compared. Further derivatization reactions to N-heterocycle-stabilized pseudocyclic diaryliodonium salts and cyclic iodoso species are presented as well.

AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein ring A, B1, B2, B3, L, R1, R2, ring Z, m and n of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula (I), intermediates and processes useful for the preparation of compounds of Formula (I).