1319255-87-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol is used as a reactant for the preparation of aminobenzimidazole urea, which serves as an antibacterial agent. Its incorporation into the synthesis process is essential for creating compounds with potent antimicrobial properties, contributing to the development of new treatments for bacterial infections.

Upstream product

• 1197193-30-8 ethyl 5-bromopyrimidine-2-carboxylate 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 
• 1193244-89-1 5-bromo-2-(1-hydroxy-1-methylethyl)pyrimidine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1384984-28-4 2-[5-(4-amino-2-fluoro-5-nitro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol 
• 1384984-30-8 (R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate 

Relevant academic research and scientific papers

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors

A series of dual-targeting, alcohol-containing benzothiazoles has been identified with superior antibacterial activity and drug-like properties. Early lead benzothiazoles containing carboxylic acid moieties showed efficacy in a well-established in vivo model, but inferior drug-like properties demanded modifications of functionality capable of demonstrating superior efficacy. Eliminating the acid group in favor of hydrophilic alcohol moieties at C 5, as well as incorporating solubilizing groups at the C7 position of the core ring provided potent, broad-spectrum Gram-positive antibacterial activity, lower protein binding, and markedly improved efficacy in vivo.

Antibacterial Compounds

The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof. Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.