131941-32-7Relevant academic research and scientific papers
An Alternative Synthetic Approach to 3-Alkylated/Arylated 5-Nitropyridines
Le, Song Thi,Asahara, Haruyasu,Nishiwaki, Nagatoshi
, p. 8856 - 8858 (2015/09/15)
An alternative method for the synthesis of 3-alkylated/arylated 5-nitropyridines was developed involving a three-component ring transformation of 3,5-dinitro-2-pyridone on treatment with aldehyde in the presence of ammonium acetate. This method facilitate
Preparation of nitropyridines by nitration of pyridines with nitric acid
Katritzky, Alan R.,Scriven, Eric F. V.,Majumder, Suman,Akhmedova, Rena G.,Vakulenko, Anatoliy V.,Akhmedov, Novraz G.,Murugan, Ramiah,Abboud, Khalil A.
, p. 538 - 541 (2007/10/03)
Preparation of nitropyridines by nitration of pyridines with nitric acid was discussed. Trifluoroacetic anhydride was chilled in an ice bath and the pyridine or substituted pyridines were slowly added and stirred at chilled conditions for 2 h. Relative amounts of the reactants were required for the nitration of pyridine were characterized by 1H and Nuclear magnetic resonance (NMR) spectroscopy and elemental analysis. It was observed that the yields of β-nitropyridines obtained using the standard protocol were generally higher than those obtained using N2O3.
