131952-81-3Relevant articles and documents
Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
Nishida, Haruyuki,Arikawa, Yasuyoshi,Hirase, Keizo,Imaeda, Toshihiro,Inatomi, Nobuhiro,Hori, Yasunobu,Matsukawa, Jun,Fujioka, Yasushi,Hamada, Teruki,Iida, Motoo,Nishitani, Mitsuyoshi,Imanishi, Akio,Fukui, Hideo,Itoh, Fumio,Kajino, Masahiro
supporting information, p. 3298 - 3314 (2017/05/29)
With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative 1b as a lead compound. As part of
4-fluorobenzoic compounds with 5-HT2 - and α1 -antagonistic activities
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, (2008/06/13)
The invention relates to the compounds of general formula I: STR1 in which: m represents an integer from 2 to 4, n and p, which may be identical or different, each represent an integer from 1 to 3, q represents 0 or 1, and R represents: either a group of formula (A): STR2 or a radical of formula (B): STR3 or a 2,4-dioxo-1,2,3,4-tetrahydroquinazolinyl radical, on condition, however, that, in this case, n and p do not simultaneously represent the number 2, or a benzhydryloxy group, or a 1-oxophthalazinyl radical, or a 5-oxothiazolo[3,2-A]pyrimidinyl radical, or a group of formula C: STR4 their possible stereoisomers and their addition salts with a pharmaceutically acceptable inorganic or organic acid. The compounds of formula I are medicinal products with useful 5-HT2 - and α1 -antagonistic activities.
