13196-41-3

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 126-81-8 dimedone 

Downstream Products

• 51924-82-4 6,6-Dimethyl-4,5,6,7-tetrahydro-4-oxo-3-phenylamino-1H-indazol 
• 894360-81-7 5,5-dimethyl-2-{[2-(4-nitro-phenyl)-2-oxo-ethylsulfanyl]-phenylamino-methylene}-cyclohexane-1,3-dione 
• 894360-77-1 5,5-dimethyl-2-[(2-oxo-2-phenyl-ethylsulfanyl)-phenylamino-methylene]-cyclohexane-1,3-dione 

Relevant academic research and scientific papers

Novel Mn2+, Fe3+, Co2+, Ni2+ and Cu2+complexes of potential OS donor thiosemicarbazide: Design, structural elucidation, anticorrosion potential study and antibacterial activity

Novel series of Co2+, Ni2+, Cu2+, Mn2+ and Fe3+complexes derived from 4,4-dimethyl-2,6-dioxo-N-phenylcyclohexanecarbothioamide (HDDPT) were prepared and characterized by conventional techniques. The c

Convenient synthesis and antibacterial activity of novel 5-phenyldiazenyl-1,3,4-thiadiazole derivatives

Reaction of N,2-diaryldiazene-1-carbohydrazonoyl chlorides 1, 2 with 2-((methylthio)-carbonthioyl)hydrazones 7, 12 and 18–21 in absolute ethanol at room temperature in the presence of triethylamine afforded the corresponding 1,3,4-thiadiazole derivatives

[HSO4]-catalyzed eco-friendly and expeditious synthesis of thiazolidine and oxazolidine derivatives

The present study reports a facile and green approach for the synthesis of thiazolidine/oxazolidine derivatives 4(a-u) in excellent yields (92-98%) with high purity. The protocol involves a one-pot three-component reaction of substituted 1,3-diketones 1(a-g), cyanates 2(a-c) and ethylchloroacetate (3) in ionic liquid [Et3NH][HSO4] under solvent-free conditions. The notable feature of this pathway is that the ionic liquid possesses both catalytic as well as medium engineering capability in this protocol. Use of [Et3NH][HSO4] as a catalyst and an environmentally benign solvent eliminates the need for a volatile organic solvent and additional catalyst. This ionic liquid is air and water stable and easy to prepare from cheap amine and acid. The present synthetic route is a green protocol offering several advantages, such as excellent yield of products, mild reaction conditions, minimizing chemical waste, shorter reaction time, simple operational procedure, easy preparation of the catalyst and its recyclability up to five cycles without any noticeable loss in catalytic activity. The protocol is applicable to a broad substrate scope. The optimization of conditions carried out in the present study revealed that 20 mol% of ionic liquid catalyst under solvent-free conditions at 120 °C are the best reaction parameters for the synthesis of thiazolidine/oxazolidine derivatives in excellent yields. This journal is

Synthesis and cycloaddition reactions of 4,4-dimethyl-2,6-dioxocyclohexane-thiocarboxamides with nitrilimines

A new series of 4,4-dimethyl-2,6-dioxocyclohexane-thiocarboxamides were prepared by reaction of aryl isothiocyanate with dimedone. Reaction of N -aryl-4,4-dimethyl-2,6-dioxocyclohexanethiocarboxamides with hydrazonoyl halides led to the formation of the corresponding thiadiazoles. Treatment of 2-[5-acetyl-3-phenyl-1,3,4-thiadiazol-2(3H)-ylidene]-5,5-dimethylcyclohexane-1,3-dione with dimethylformamide dimethylacetal (DMF-DMA) in refluxing dioxane afforded (E )-2-[5-(3-(dimethylamino)acryloyl)-3-phenyl-1,3,4-thiadiazol-2(3H)-ylidene]-5,5-dimethylcyclohexane-1,3-dione. Reaction of the latter enaminone with hydrazonoyl halides yielded the corresponding 2-(1-aryl-3-substituted-pyrazol-4-carbonyl)-5-[3-phenyl-5-(5,5-dimethylcyclohexane-1,3-dione)-[1,3,4]-thiadiazole] derivatives. The structures of the new compounds were elucidated on the basis of their elemental analyses and spectral data.

Synthesis of some new thiazole, thiophene, and 2,3-dihydro-1,3,4- thiadiazole and pyrimidino[1,2-b]indazole derivatives

Hydrazonoyl halides 4a-g reacted with methyl carbodithioate 3 thioanilide 10 to give 1,3,4-thiadiazoles 5a-g and 13a-g, respectively. Thioanilide 10 reacted with ω-bromoacetophenones 14a-e to give the acyclic product 15a-e, which was converted to the thio

The crystal and molecular structure of cyclic thioamide β-diketone derivatives. Intramolecular H-bonding and the problem of quasiaromaticity

Crystal and molecular structures of the 2,6-dioxocyclohexanethiocarboxanilide (I), 4,4-dimethyl-2,6-dioxocyclohexanethiocarboxanilide (II) and 1,3-indandione-2-thiocarboxanilide (III) have been determined by use of X-ray diffraction technique on a Kuma-di