51924-82-4

Upstream product

• 13196-41-3 N-phenyl-4,4-dimethyl-2,6-dioxocyclohexane-1-carbothioamide 
• 97405-18-0 2-amino-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-enecarbothioamide 
• 103-72-0 phenyl isothiocyanate 
• 126-81-8 dimedone 
• 7721-63-3 2-hydroxy-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide 
• 894360-91-9 5,5-dimethyl-2-[methylthio(phenylamino)methylene]cyclohexane-1,3-dione 
• 60-34-4 methylhydrazine 

Relevant academic research and scientific papers

One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives

A series of highly functionalized pyrazole derivatives has been prepared by a one-pot, versatile and regioselective procedure. Pyrazoles 1–29 were tested in cell-based assay to assess their antiproliferative activity against a panel of tumour cells. Addit

Spectroscopic, X-ray and DFT studies of prototropic tautomerism and photophysical properties of regioselectively designed new 3-, 2,3-substituted tetrahydro[4H]indazol-4-ones

Reaction of dimedone and arylisothiocyanate in triethyl amine produced carbothioamide 2 which on condensation with hydrazine or phenyl hydrazine generated 3-substitued-2H-indazole 3 or 2,3-disubstituted-2H-indazole 5, respectively instead of the expected

A simple and efficient diversity-oriented synthesis of new substituted 3-(Arylamino)-6,7-dihydro-1H-indazol-4(5H)-ones by a KOH-assisted one-pot reaction

A novel, simple, and straightforward combinatorial method for the synthesis of new substituted 3-(arylamino)-6,7-dihydro-1H-indazol-4(5H)-one derivatives has been developed. The synthesis was achieved via a one-pot three-component reaction of aromatic isothiocyanates, substituted 1,3-cyclohexanediones, and hydrazine hydrate in dimethyl sulfoxide as a polar aprotic solvent. This methodology has the advantages of mild reaction conditions, good to excellent yields, easily available starting materials, operational simplicity, and easy workup. This chemistry provides an efficient synthetic strategy to diversity-oriented construction of the 3-arylaminoindazole skeleton.

Synthesis of some new thiazole, thiophene, and 2,3-dihydro-1,3,4- thiadiazole and pyrimidino[1,2-b]indazole derivatives

Hydrazonoyl halides 4a-g reacted with methyl carbodithioate 3 thioanilide 10 to give 1,3,4-thiadiazoles 5a-g and 13a-g, respectively. Thioanilide 10 reacted with ω-bromoacetophenones 14a-e to give the acyclic product 15a-e, which was converted to the thio