131966-91-1Relevant academic research and scientific papers
Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors
Li, Wen-Ren,Peng, Shao-Zheng
, p. 7373 - 7376 (2007/10/03)
The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.
Amino Acid Esters as Chiral Auxiliaries in Barbier-Type Reactions in Aqueous Solution
Waldmann, Herbert
, p. 1317 - 1322 (2007/10/02)
Valine and proline benzyl ester are converted into the aliphatic and aromatic α-oxo amides 5 by activation of the respective α-oxo acid by means of N,N'-diisopropylcarbodiimide.The α-oxo amides 5 undergo Barbier-type reactions with differently substituted
