131968-24-6Relevant academic research and scientific papers
Amine-effected cyclization of chalcone dihalides to aurones
Donnelly, John A.,Emerson, Geraldine M.
, p. 7227 - 7236 (2007/10/02)
The possibility of employing the amine-catalysed cyclization of αβ-dibromodihydrochalcones and α-bromochalcones as a general synthesis of aurones was studied using cyclohexylamine and the most representative member of each class of these αβ-disubstituted ketones and α-halogeno chalcones. Overall yields of heterocyclic products were generally poor except from 4′6′-dimethoxy- and 3-nitro-substituted chalcone systems; aurones were obtained in fair yield from the former and in excellent yield from the latter. 22′-Diacetoxychalcone dibromide and 22′-diacetoxy-α-bromochalcone cyclised to a 2-benzoylbenzofuran to the exclusion of the corresponding aurone and flavone.
