131971-66-9Relevant articles and documents
In Situ Preparation and Subsequent Use of Isomerically Pure E- and Z-Crotylamines in a 3-Aza-Claisen Rearrangement
Walters, M. A.,Hoem, A. B.
, p. 2645 - 2647 (1994)
-
Enantioselective and Regiodivergent Functionalization of N-Allylcarbamates by Mechanistically Divergent Multicatalysis
Richmond, Edward,Khan, Ismat Ullah,Moran, Joseph
supporting information, p. 12274 - 12277 (2016/08/24)
A pair of mechanistically divergent multicatalytic reaction sequences has been developed consisting of nickel-catalyzed isomerization of N-allylcarbamates and subsequent phosphoric-acid-catalyzed enantioselective functionalization of the resulting intermediates. By appropriate selection of reaction partners, in situ generated imines and ene-carbamates are mechanistically partitioned to yield opposing functionalized products. Formal α-functionalization to give protected α-arylamines is achieved upon enantioselective Friedel–Crafts reaction with arene nucleophiles, whereas formal β-functionalization is achieved upon reaction with diarylimine electrophiles in an enantioselective Povarov-[4+2] cycloaddition.
Syntheses of hydroxamic acid-containing bicyclic β-lactams via palladium-catalyzed oxidative amidation of alkenes
Jobbins, Maria O.,Miller, Marvin J.
, p. 1620 - 1625 (2014/03/21)
Palladium-catalyzed oxidative amidation has been used to synthesize hydroxamic acid-containing bicyclic β-lactam cores. Oxidative cleavage of the pendant alkene provides access to the carboxylic acid in one step.