1319746-34-3Relevant academic research and scientific papers
Oligophenylenaminones as scaffolds for α-helix mimicry
Adler, Marc J.,Hamilton, Andrew D.
, p. 7040 - 7047 (2011/10/08)
The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix- mediated protein-protein interactions. In our studies we have continued to develop novel, more biologically compatible scaffolds, which are often easier to assemble and capable of mimicking longer and/or more diverse helices. To this end, we have constructed a new series of i, i+4, i+7 α-helix mimics based on the enaminone scaffold. These molecules represent a step forward in the pursuit of idealized monofacial α-helix mimetics.
