131998-24-8

Basic information

• Product Name: 5,7-Dichloro-1,8-naphthyridin-2-amine
• Synonyms: 5,7-Dichloro-1,8-naphthyridin-2-amine
• CAS NO: 131998-24-8
• Molecular Formula: C8H5Cl2N3
• Molecular Weight: 214.0514
• Mol File: 131998-24-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 213-216 °C
• Boiling Point: 364.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.571±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.34±0.30(Predicted)
• CAS DataBase Reference: 5,7-Dichloro-1,8-naphthyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dichloro-1,8-naphthyridin-2-amine(131998-24-8)
• EPA Substance Registry System: 5,7-Dichloro-1,8-naphthyridin-2-amine(131998-24-8)

Safety Data

• Hazardous Substances Data: 131998-24-8(Hazardous Substances Data)

Usage

General Description

5,7-Dichloro-1,8-naphthyridin-2-amine, also known as DCNA, is a chemical compound with the molecular formula C12H7Cl2N3. It is a member of the naphthyridine family and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. DCNA is a white to off-white crystalline powder with a melting point of 218-220°C. It is a versatile compound with a wide range of applications, including the development of anti-tumor drugs and the control of plant pathogens. Additionally, DCNA is known for its high solubility in polar organic solvents and its stable nature, making it a valuable component in various chemical processes.

Upstream product

• 199983-20-5 N-(5,7-Dihydroxy-[1,8]naphthyridin-2-yl)-acetamide 
• 141-86-6 2.6-diaminopyridine 
• 76541-91-8 7-amino-1,8-naphthyridine-2,4-diol 
• 199983-19-2 7-acetamido-2,4-dichloro-1,8-naphthyridine 

Relevant articles and documents

Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents - Part VII

A series of 2-(carbethoxypiperazinyl)- and 2-piperazinyl-1,8- naphthyridine derivatives, variously substituted, have been synthesized and pharmacologically investigated for their antihypertensive activity. Some of them exhibited a significant and prolonged decrease of the mean arterial pressure (MAP) on spontaneously hypertensive rats. For this series of compounds, on the basis of the pharmacological results obtained, no structure-activity relationship can be deduced at this time. Moreover, the most active and representative compounds 11b, 12a and 16b were investigated by means of in vitro pharmacological functional studies and in vivo, as diuretic agents, to determine a possible mechanism of the antihypertensive activity, which is unknown for the moment.

Substituted 1,8-naphthyridines, their preparation and their use as antidotes

A combination of a variety of herbicides with safening agents which are substituted 1,8-naphthyridines of the formula STR1 where R1 is mercapto, hydroxyl, halogen, benzylthio, amino or NR2 R3, where R2 is a grou