76541-91-8

Usage

Uses

Used in Pharmaceutical Industry:
7-Amino-4-hydroxy-1,8-naphthyridin-2(1H)-one is used as an intermediate in the synthesis of pharmaceuticals for its pharmacological properties and potential in the development of drugs targeting various diseases and conditions.
Used in Research Chemicals:
7-Amino-4-hydroxy-1,8-naphthyridin-2(1H)-one is used as a research chemical to study and develop new therapeutic agents due to its unique molecular structure and properties.

Upstream product

• 141-86-6 2.6-diaminopyridine 
• 105-53-3 diethyl malonate 
• 131998-49-7 2-acetylamino-5-hydroxy-7-acetoxy-1,8-naphthyridine 
• 131998-50-0 2-acetylamino-5-acetoxy-7-hydroxy-1,8-naphthyridine 

Downstream Products

• 131998-24-8 5,7-dichloro-1,8-naphthyridin-2-amine 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR INHIBITING mTOR

Compounds having activity as mTOR inhibitors are disclosed. The compounds have the following structure (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Microwave assisted synthesis of some 2, 4 dihydroxy 1, 8-naphthyridines and their derivatives devoid of solvent and catalyst

Reaction of substituted 2-aminopyridines with diethylmalonates yields 2, 4- dihydroxy-l, 8-Naphthyridenes(l-18). The 6-chloro-2, 4-dihydroxy-l, 8- naphthyridene (5) when treated with different reagents varied substituted derivatives are produced. 6- chloro-2, 4-dihydroxy-l, 8-naphthyridene(5) when treated with sodium azide offered 2, 4-dihydroxy-1, 8-naphthyridene-6-thiones (19-21). 6-azido-1, 8-naphthyridine-2, 4- diols(22-24) were obtained by reacting 5 with sodiumazide. The 6-hydrazinyl-l, 8-naphthyridine-2, 4-diols (25-27) and 2, 4, 6-trihydroxy-l, 8-naphthyridenes (28-30) were produced by the reaction of 5 with hydrazine hydrate and acetic acid respectively.

Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents - Part VII

A series of 2-(carbethoxypiperazinyl)- and 2-piperazinyl-1,8- naphthyridine derivatives, variously substituted, have been synthesized and pharmacologically investigated for their antihypertensive activity. Some of them exhibited a significant and prolonged decrease of the mean arterial pressure (MAP) on spontaneously hypertensive rats. For this series of compounds, on the basis of the pharmacological results obtained, no structure-activity relationship can be deduced at this time. Moreover, the most active and representative compounds 11b, 12a and 16b were investigated by means of in vitro pharmacological functional studies and in vivo, as diuretic agents, to determine a possible mechanism of the antihypertensive activity, which is unknown for the moment.

Substituted 1,8-naphthyridines, their preparation and their use as antidotes

A combination of a variety of herbicides with safening agents which are substituted 1,8-naphthyridines of the formula STR1 where R1 is mercapto, hydroxyl, halogen, benzylthio, amino or NR2 R3, where R2 is a grou