132-69-4 Usage
Description
Benzydamine hydrochloride is a non-steroidal antiinflammatory
drug used both topically and systemically.
It has been reported as a sensitizer and a
photosensitizer and caused occupational contact dermatitis
in a nurse.
Chemical Properties
Off-White Solid
Originator
Tantum,Angelini
Uses
Different sources of media describe the Uses of 132-69-4 differently. You can refer to the following data:
1. A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
2. anticholinergic
3. A nonsteroidal anti-inflammatory with local anesthetic properties.
4. Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.
Manufacturing Process
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120
ml of concentrated hydrochloric acid at 25°C was added concentrated solution
of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in
1.5 L of water. To this solution under nitrogen was added 400 g of sodium
bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The
obtained solid product was dissolved in water and then to the solution was
added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)
propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
Brand name
Tantum (Angelini Francesco, Italy).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Contact allergens
It is a nonsteroidal anti-inflammatory drug used both
topically and systemically. It has been reported as a
sensitizer and a photosensitizer.
Side effects
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
Safety Profile
Poison by
intraperitoneal, subcutaneous, and
intravenous routes. Moderately toxic by
ingestion. An experimental teratogen. Other
experimental animal reproductive effects.
An eye irritant. A nonsteroidal antiinflammatory
analgesic. When heated to
decomposition it emits very toxic fumes of
HCl and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 132-69-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 132-69:
(5*1)+(4*3)+(3*2)+(2*6)+(1*9)=44
44 % 10 = 4
So 132-69-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
132-69-4Relevant articles and documents
Manufacturing of benzydamine purification of benzydamine using steam distillation
-
, (2008/06/13)
A method for removing a 1-chloro-3-dimethylaminopropane impurity from a benzydamine crude product which comprises steam distillation.
