132017-56-2

Upstream product

• 4509-90-4 5-bromovaleroyl chloride 
• 201230-82-2 carbon monoxide 
• 128900-61-8 3-vinyl-(S)-4-phenyl-2-oxazolidinone 

Downstream Products

• 201680-41-3 (S)-3-((4S,5S)-2-Oxo-1,6-dioxa-spiro[4.5]dec-4-yl)-4-phenyl-oxazolidin-2-one 
• 201680-51-5 (S)-4-Phenyl-3-((4S,5S)-2-phenylsulfanyl-1,6-dioxa-spiro[4.5]dec-4-yl)-oxazolidin-2-one 
• 201680-62-8 (S)-3-((4S,5S)-2-Benzenesulfonyl-1,6-dioxa-spiro[4.5]dec-4-yl)-4-phenyl-oxazolidin-2-one 
• 201680-54-8 (S)-3-(4S,5S)-1,6-Dioxa-spiro[4.5]dec-2-en-4-yl-4-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis and Reactivity of Optically Active Spiroketals by Ring-Expansion of Chromium Carbene Complex-Derived Cyclobutanones

Photolysis of cyclic chromium alkoxycarbene complexes with an optically active ene-carbamate gave spirofused, optically active cyclobutanones. Baeyer-Villiger ring expansion followed by further functionalization gave optically active spiroketals. Photochemical ring expansion of these spirofused cyclobutanones in the presence of acetic acid or thiophenol gave 2-acetoxy- or 2-(thiophenoxy)-4- spirofused tetrahydrofurans. Elimination of the thiophenoxy group gave a 3,4-dihydrofuran that underwent Heck arylation and photochemical cycloaddition with chromium carbene complexes to give cyclobutanones.

Synthesis of optically active cyclobutanones by the photolysis of chromium-alkoxycarbene complexes in the presence of optically active ene-carbamates

Optically active ene-carbamates derived from (S)-phenylglycine were allowed to photochemically react with à variety of (alkoxy)(alkyl)chromium-carbene complexes. Cyclobutanones were formed in fair to good yield with generally excellent control of stereoch