201680-54-8

Upstream product

• 201680-62-8 (S)-3-((4S,5S)-2-Benzenesulfonyl-1,6-dioxa-spiro[4.5]dec-4-yl)-4-phenyl-oxazolidin-2-one 
• 128900-61-8 3-vinyl-(S)-4-phenyl-2-oxazolidinone 
• 201680-51-5 (S)-4-Phenyl-3-((4S,5S)-2-phenylsulfanyl-1,6-dioxa-spiro[4.5]dec-4-yl)-oxazolidin-2-one 
• 132017-56-2 (S)-3-((1S,4R)-3-Oxo-5-oxa-spiro[3.5]non-1-yl)-4-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis and Reactivity of Optically Active Spiroketals by Ring-Expansion of Chromium Carbene Complex-Derived Cyclobutanones

Photolysis of cyclic chromium alkoxycarbene complexes with an optically active ene-carbamate gave spirofused, optically active cyclobutanones. Baeyer-Villiger ring expansion followed by further functionalization gave optically active spiroketals. Photochemical ring expansion of these spirofused cyclobutanones in the presence of acetic acid or thiophenol gave 2-acetoxy- or 2-(thiophenoxy)-4- spirofused tetrahydrofurans. Elimination of the thiophenoxy group gave a 3,4-dihydrofuran that underwent Heck arylation and photochemical cycloaddition with chromium carbene complexes to give cyclobutanones.