132017-97-1Relevant academic research and scientific papers
Sigma receptor ligands and the use thereof
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, (2008/06/13)
The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.
Identification and Exploitation of the ?-Opiate Pharmacophore
Glennon, Richard A.,Smith, J. Doyle,Ismaiel, Abd M.,El-Ashmawy, Mahmoud,Battaglia, George,Fisher, James B.
, p. 1094 - 1098 (2007/10/02)
Certain benzomorphan "?-opiates" such as N-allylnormetazocine (NANM) bind at ? receptors with modest affinity and with little selectivity (i.e., they also bind at phencyclidine or PCP sites).In order to identify the primary pharmocophore of the benzomorph
