622-86-6

Basic information

• Product Name: 2-Phenoxyethyl chloride
• Synonyms: (2-chloroethoxy)-benzen;1-Phenoxy-2-chloroethane;benzene,(2-chloroethoxy);benzene,(2-chloroethoxy)-;beta-Phenoxyethyl chloride;-Chlorophenetole;Ether, 2-chloroethyl phenyl;Phenetole, beta-chloro-
• CAS NO: 622-86-6
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.61
• EINECS: 210-757-0
• Product Categories: Pharmaceutical Intermediates;Phenetole;Aromatics Compounds;Aromatics
• Mol File: 622-86-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 28°C
• Boiling Point: 97-98 °C15 mm Hg(lit.)
• Flash Point: 213 °F
• Appearance: Pale yellow oil
• Density: 1.129 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.178mmHg at 25°C
• Refractive Index: n20/D 1.534(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Ethyl Acetate
• BRN: 971048
• CAS DataBase Reference: 2-Phenoxyethyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenoxyethyl chloride(622-86-6)
• EPA Substance Registry System: 2-Phenoxyethyl chloride(622-86-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3265
• WGK Germany: 3
• F: 10-21
• TSCA: Yes
• Hazardous Substances Data: 622-86-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

Different sources of media describe the Uses of 622-86-6 differently. You can refer to the following data:
1. Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.
2. (2-Chloroethoxy)benzene is used in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane and anisole in the synthesis of pseudo-symmetrical tamoxifen derivatives.

InChI:InChI=1/C8H9ClO/c9-6-7-10-8-4-2-1-3-5-8/h1-5H,6-7H2

Upstream product

• 107-06-2 1,2-dichloro-ethane 
• 108-95-2 phenol 
• 100-67-4 potassium phenolate 
• 107-04-0 1-Bromo-2-chloroethane 
• 139-02-6 sodium phenoxide 
• 64-17-5 ethanol 
• 122-99-6 2-Phenoxyethanol 
• 56-93-9 benzyltrimethylammonium chloride 
• 122-59-8 2-phenoxyacetic acid 
• 141482-06-6 1-methanesulfonyloxy-2-(phenoxy)ethane 
• 67-68-5 dimethyl sulfoxide 
• 104-15-4 toluene-4-sulfonic acid 
• 56-23-5 tetrachloromethane 
• 80-41-1 2-chloroethyl tosylate 

Downstream Products

• 13380-49-9 (4-(2-chloroethoxy)phenyl)(4-methoxyphenyl)methanone 
• 101782-14-3 2-[bis-(2-phenoxy-ethyl)-amino]-ethanol 
• 17414-04-9 β-phenyl mercaptoethyl phenolate 
• 666836-96-0 1-[4-(2-chloro-ethoxy)-phenyl]-decan-1-one 
• 41378-51-2 N-ethyl-N-(2-phenoxy-ethyl)-aniline 
• 622-18-4 N-(2-phenoxyethyl)aniline 
• 25347-73-3 4,4'-Bis-(2-chlor-ethoxy)-stilben 
• 1558-90-3 2-phenoxyethylmalonic acid ethyl ester 
• 55246-89-4 N-n-propyl-N-2-phenoxy-ethyl amine 
• 1357000-38-4 4,4,5,5-tetramethyl-2-(2-phenoxyethyl)-1,3,2-dioxaborolane 
• 64009-16-1 2-(2,4-Dichlorphenyl)-4-phenoxybutyronitril 
• 55247-31-9 N-(2-Phenoxyethyl)benzylamine 
• 162616-45-7 Ph₂P(CH₂)2OPh 
• 73941-29-4 O-(2-phenoxyethyl)hydroxylamine 

Relevant articles and documents

NMP-mediated chlorination of aliphatic alcohols with aryl sulfonyl chloride for the synthesis of alkyl chlorides

NMP-mediated chlorination of aliphatic alcohols has been developed for the synthesis of alkyl chlorides. This facile, efficient and practical approach used simple and readily available aryl sulfonyl chlorides as the chlorination reagent for the construction of C–Cl bond in good to excellent yields with mild conditions and broad substrate scope.

Formononetin derivatives and preparation methods and medical application thereof

The invention relates to the field of pharmaceutical chemistry, and relates to formononetin derivatives and preparation methods and medical application thereof, in particular to formononetin derivatives with the general formula as shown in (I), preparation methods thereof, pharmaceutical compositions containing the compounds and medical application of the derivatives and the pharmaceutical compositions, particularly, application of the derivatives and the pharmaceutical compositions serving as drugs for preventing or treating hyperlipidaemia or obesity or type-II diabetes. Please see the formula in the description.

Method for preparing chlorohydrocarbons from alcohols by using aryl sulfonyl chloride as chlorination agent

The invention provides a method for preparing chlorohydrocarbons from alcohols by using aryl sulfonyl chloride as a chlorination agent. The method comprises the following steps: heating alcohols and aryl sulfonyl chloride in N,N-dialkyl substituted amide to react for 30 minutes, cooling the reaction product to room temperature, adding dichloromethane and water, carrying out extraction and skimming, washing the organic layer with saturated saline water, drying with anhydrous sodium sulfate, steaming to remove the solvent, and carrying out further separation and purification to obtain the chlorohydrocarbons. The method has the characteristics of cheap and accessible chlorination agent, simple technical process, short reaction time and the like, can obtain high reaction under the condition that the aryl sulfonyl chloride consumption is approximate to the stoichiometric quality, and can remove the reaction byproduct aryl sulfonic acid from the reaction mixture.