1320275-51-1Relevant articles and documents
4-Alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation
Xiao, Zhu-Ping,Ouyang, Hui,Wang, Xu-Dong,Lv, Peng-Cheng,Huang, Ze-Jun,Yu, She-Rong,Yi, Tian-Fang,Yang, Ye-Ling,Zhu, Hai-Liang
, p. 3884 - 3891 (2011/08/02)
A series of novel 4-alkoxy-3-arylfuran-2(5H)-ones as tyrosyl-tRNA synthetase inhibitors were synthesized. Of these compounds, 3-(4-hydroxyphenyl)- 4-(2-morpholinoethoxy)furan-2(5H)-one (27) was the most potent. The binding model and structure-activity rel